Pyridine-phosphinimine ligand-accelerated Cu(i )-catalyzed azide–alkyne cycloaddition for preparation of 1-(pyridin-2-yl)-1,2,3-triazole derivatives
| Autor: | Jiudong Zhao, Hao Zhang, Ranfeng Sun, Jianfeng Hu, Huangdong Wang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Azides
1 2 3-Triazole Double bond Pyridines Stereochemistry Molecular Conformation Alkyne Ligands Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound Pyridine Physical and Theoretical Chemistry chemistry.chemical_classification Cycloaddition Reaction Ligand Organic Chemistry Triazoles Cycloaddition chemistry Alkynes Imines Azide Copper |
| Zdroj: | Organic & Biomolecular Chemistry. 12:5954 |
| ISSN: | 1477-0539 1477-0520 |
| Popis: | A series of phosphinimine ligands were designed and used in the Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of tetrazolo[1,5-a]pyridines and alkynes for the first time. By optimizing the reaction conditions, an efficient catalytic system (CuCl/2-PyCH2N[double bond, length as m-dash]P(t)Bu3) was developed to give 1-(pyridin-2-yl)-1,2,3-triazole derivatives in moderate to excellent yields (46-98%). |
| Databáze: | OpenAIRE |
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