Associations of serum brain-derived neurotrophic factor with cognitive impairments and negative symptoms in schizophrenia
| Autor: | Makoto Asano, Mihisa Fujisaki, Masaomi Iyo, Sho Kimura, Tasuku Hashimoto, Hiroyuki Watanabe, Tomihisa Niitsu, Kenji Hashimoto, Nobuhisa Kanahara, Yukihiko Shirayama, Tetsuya Shiraishi, Daisuke Matsuzawa, Michiko Nakazato, Tadashi Hasegawa, Akihiro Shiina, Goro Fukami |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Neuropsychological Tests behavioral disciplines and activities Neurotrophic factors Internal medicine mental disorders Schizophrenic Psychology medicine Humans Scale for the Assessment of Negative Symptoms Biological Psychiatry Pharmacology Brain-derived neurotrophic factor Working memory Brain-Derived Neurotrophic Factor Neuropsychology Cognition Middle Aged medicine.disease Memory Short-Term Schizophrenia Female Cognition Disorders Psychology Clinical psychology |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 35:1836-1840 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2011.09.004 |
| Popis: | Brain-derived neurotrophic factor (BDNF) may be involved in the pathophysiology of schizophrenia. The aim of this study was to examine the associations of serum BDNF levels with the cognition and clinical characteristics in patients with schizophrenia. Sixty-three patients with schizophrenia and 52 age- and sex-matched healthy controls were examined with neuropsychological tests. Serum BDNF levels were determined by enzyme-linked immunosorbent assay (ELISA). There were no significant differences in serum BDNF levels between normal controls and patients with schizophrenia. Serum BDNF levels of normal controls showed negative correlations with verbal working memory, but this was not the case with schizophrenic patients. Meanwhile, serum BDNF levels of schizophrenic patients showed positive correlations with the scores of the Scale for the Assessment of Negative Symptoms (SANS) and the Information subtest scores of Wechsler Adult Intelligence Scale Revised (WAIS-R). Serum BDNF levels are related with the impairment of verbal working memory and negative symptoms in patients with schizophrenia. |
| Databáze: | OpenAIRE |
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