Unique patterns of FOS, phospho-CREB and BrdU immunoreactivity in the female rat brain following chronic stress and citalopram treatment
| Autor: | Andrea Trentani, Clive R. Bramham, Ido P. Kema, Sjoukje D. Kuipers, Christel Westenbroek, ter Gert Horst, den Johan Boer, Jakob Korf |
|---|---|
| Přispěvatelé: | Guided Treatment in Optimal Selected Cancer Patients (GUTS), Lifestyle Medicine (LM) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
c-fos medicine.medical_specialty SEROTONIN REUPTAKE INHIBITORS Hippocampal formation Citalopram Weight Gain c-Fos CELL-PROLIFERATION Cellular and Molecular Neuroscience chemistry.chemical_compound Neurochemical NEUROTROPHIC FACTOR EXPRESSION ADULT-RAT Corticosterone Internal medicine Neuroplasticity medicine Animals Chronic stress citalopram TRANSCRIPTION FACTOR Rats Wistar BrdU phospho-CREB Pharmacology Electroshock biology Dentate gyrus CREB-Binding Protein Immunohistochemistry footshock Rats ANTIDEPRESSANT DRUGS Endocrinology female chemistry Bromodeoxyuridine DENTATE GYRUS biology.protein Antidepressive Agents Second-Generation LONG-TERM POTENTIATION Psychology MESSENGER-RNA Proto-Oncogene Proteins c-fos Stress Psychological medicine.drug |
| Zdroj: | Neuropharmacology, 50(4), 428-440. PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/j.neuropharm.2005.10.006 |
| Popis: | Affective disorders are common psychiatric illnesses characterized by marked gender-related prevalence. Recent evidence links chronic stress and dysregulation of neurotrophin signaling with the development of depression, while novel theories suggest that antidepressants may act by promoting intracellular adaptations linked to neuroplasticity. Although selective serotonin reuptake inhibitors (SSRIs) efficaciously improve a variety of dysfunctions in males, their neuroendocrine effects and intracellular signaling patterns in females are not well determined. Here we show that chronic footshock stress (21 days) promotes HPA axis hyperactivity (as seen by the increased FOS-ir in the paraventricular hypothalamic nucleus (PVN), plasma corticosterone and adrenal hypertrophy), reduces hippocampal BrdU immunoreactivity and suppresses cortical-limbic CREB phosphorylation in female rats. Long-term citalopram treatment, in contrast. attenuates stress-induced elevation of corticosterone levels and adrenal hypertrophy, although it does not reverse footshock-mediated induction of FOS-ir in the PVN, inhibition of CREB phosphorylation and reduction of hippocampal BrdU-Iabeling. Moreover, citalopram administration was also associated with significant hypophagic effects and inhibition of CREB phosphorylation. These data suggest that, in female rats, normalization of chronic stress-induced HPA axis abnormalities may represent an initial phase of citalopram-mediated therapeutic actions and despite this SSRI's apparent lack of effects on neuroplasticity, we cannot exclude the possibility that some neurochemical adaptations occur in a later stage which may require more than 3 weeks of treatment to manifest. (c) 2005 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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