Exercise-induced modulation of histone H4 acetylation status and cytokines levels in patients with schizophrenia
| Autor: | Daniela Pochmann, Caroline Lavratti, Alessandra Peres, Lucas L. Schipper, Gilson Pires Dorneles, Pedro Dal Lago, Luciane Carniel Wagner, Andreia Bard, Viviane Rostirola Elsner |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Time Factors Hydrocortisone medicine.medical_treatment Experimental and Cognitive Psychology Peripheral blood mononuclear cell Statistics Nonparametric Histones Histone H4 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Internal medicine Humans Medicine Interferon gamma Exercise biology business.industry Acetylation Resistance Training Middle Aged medicine.disease 030104 developmental biology Endocrinology Cytokine Histone Schizophrenia Immunology biology.protein Cytokines Female business Body mass index 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Physiology & Behavior. 168:84-90 |
| ISSN: | 0031-9384 |
| Popis: | The present study aimed to investigate the short and long-term effects of a concurrent exercise protocol on global histone H4 acetylation levels and inflammatory markers (interleukin-4 (IL-4), interleukin-6 (IL-6), interferon gamma (IFN-γ) and cortisol) in phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMC) and in peripheral blood of patients with schizophrenia (SZ), as well the intervention impact on anthropometric characteristics. Seventeen individuals were submitted to the intervention three times a week and blood samples were collected pre, 30, 60 and 90days after the intervention started. A remarkable reduction on body mass index and body mass were observed following intervention. The protocol also induced a histone H4 hypoacetylation status in PBMC all times evaluated when compared to the pre intervention period. Although the IL-4 and cortisol levels were not altered in response to the intervention, a reduction in IL-6 production during the 60 and 90days compared to the pre intervention period was observed. Finally, diminished IFN-γ production was found in the 90days period compared to the pre intervention and 30days after periods. In addition, systemic IL-6 levels were lower at 60 and 90days compared to the pre intervention. The concurrent exercise protocol was able to improve anthropometric characteristics in patients with SZ, engaging the modulation of cytokine and histone H4 acetylation levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect