| Autor: |
Shigeru Yamaguchi, Motomu Kanai, Harunobu Mitsunuma, Yohei Shimizu, Hiroyasu Nakao, Xiang-Ning Zhai, Hongyu Chen, Yuya Morita |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.26434/chemrxiv.14579169 |
| Popis: |
Asymmetric catalysis enabling divergent control of multiple stereocenters remains challenging in synthetic organic chemistry. While machine learning-based optimization of molecular catalysis is an emerging approach, data-driven catalyst design to achieve stereodivergent asymmetric synthesis producing multiple reaction outcomes, such as constitutional selectivity, diastereoselectivity, and enantioselectivity, is unprecedented. Here, we report the straightforward identification of asymmetric two-component iridium/boron hybrid catalyst systems for α-C-allylation of carboxylic acids. Structural optimization of the chiral ligands for iridium catalysts was driven by molecular field-based regression analysis with a dataset containing overall 32 molecular structures. The catalyst systems enabled selective access to all the possible isomers of chiral carboxylic acids bearing contiguous stereocenters. This stereodivergent asymmetric catalysis is applicable to late-stage structural modifications of drugs and their derivatives. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
