Differential effects of leukotriene C4 on endothelin-1 and prostacyclin release by cultured vascular cells
| Autor: | Carlo Patrono, Paola Patrignani, F Bertolero, R Modica |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Prostacyclin 6-Ketoprostaglandin F1 alpha Biology Muscle Smooth Vascular chemistry.chemical_compound Internal medicine medicine Animals Protein kinase C Cells Cultured Pharmacology Leukotriene C4 Activator (genetics) Kinase Endothelins Endothelin 1 Epoprostenol Stimulation Chemical Endothelial stem cell Endocrinology chemistry Phorbol Tetradecanoylphorbol Acetate Cattle SRS-A Endothelium Vascular medicine.drug |
| Zdroj: | Pharmacological research. 27(3) |
| ISSN: | 1043-6618 |
| Popis: | Nanomolar concentrations of leukotriene C4 and phorbol 12-myristate acetate, a protein kinase C activator, stimulated endothetin-1 release by vascular endothelial but not smooth muscle cells. For both agonists, attenuation of this stimulatory effect was observed at higher concentrations, concomitant with but independent of enhanced prostacyclin biosynthesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|