Applications of Bone Morphogenetic Protein-2: Alternative Therapies in Craniofacial Reconstruction
| Autor: | Neil Tanna, James P. Bradley, Mark Fisher, Nicholas Bastidas, Brandon Alba, Kristen Yee |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Complementary Therapies
medicine.medical_specialty Alternative therapy Bone Morphogenetic Protein 2 Mandible Bone morphogenetic protein Bone morphogenetic protein 2 03 medical and health sciences 0302 clinical medicine Transforming Growth Factor beta Cranial vault Medicine Humans Craniofacial skeleton Prospective Studies Craniofacial 030223 otorhinolaryngology Bone Transplantation business.industry Skull 030206 dentistry General Medicine Plastic Surgery Procedures Autologous bone Recombinant Proteins Surgery Otorhinolaryngology Collagen business Demineralized bone |
| Zdroj: | The Journal of craniofacial surgery. 30(7) |
| ISSN: | 1536-3732 |
| Popis: | Large defects of the craniofacial skeleton can be exceedingly difficult to reconstruct since autologous bone grafts are limited by donor site morbidity and alloplastic implants have low biocompatibility. Bone morphogenetic proteins (BMPs) in craniofacial reconstruction have been used with mixed outcomes and complication concerns; however, results for specific indications have been promising.In alveolar clefts, cranial vault defects, mandibular defects, and rare Tessier craniofacial clefts, BMP-2 impregnated in collagen matrix was looked at as an alternative therapy for challenging cases. In cases where structural support was required, BMP-2 was used as part of a construct with bio-resorbable plates. Demineralized bone was added in certain cases.The authors described specific indications, detailed surgical techniques, and a review of the current literature regarding the use of BMP-2 in craniofacial reconstruction. BMP-2 is a viable option for craniofacial reconstruction to decrease donor-site morbidity or when alternatives are contraindicated. It is not recommended for routine use or in the oncologic setting but should currently be reserved as an alternative therapy for complex cases with limited options.Bone morphogenetic proteins are a promising, emerging option for complex craniofacial reconstruction. Future directions of BMP-2 therapies will become apparent as data from prospective randomized trials emerges. |
| Databáze: | OpenAIRE |
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