Anti-cancer activity of myricetin against human papillary thyroid cancer cells involves mitochondrial dysfunction–mediated apoptosis
| Autor: | Tae Kwun Ha, Inae Jung, Sung Kwon Bae, Jun Sik Lee, Mi Eun Kim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antineoplastic Agents Apoptosis Papillary thyroid cancer 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor Internal medicine medicine Humans Thyroid Neoplasms Anaplastic thyroid cancer Thyroid cancer Caspase bcl-2-Associated X Protein Cell Nucleus Flavonoids Pharmacology biology Cell Cycle Apoptosis Inducing Factor Cancer General Medicine Cell cycle medicine.disease Carcinoma Papillary Mitochondria 030104 developmental biology Endocrinology chemistry Thyroid Cancer Papillary Caspases 030220 oncology & carcinogenesis biology.protein Cancer research Myricetin |
| Zdroj: | Biomedicine & Pharmacotherapy. 91:378-384 |
| ISSN: | 0753-3322 |
| Popis: | Thyroid cancer is the most common endocrine malignancy and can range in severity from relatively slow-growing occult differentiated thyroid cancer to uniformly aggressive and fatal anaplastic thyroid cancer. A subset of patients with papillary thyroid cancer present with aggressive disease that is refractory to conventional treatment. Myricetin is a flavonol compound found in a variety of berries as well as walnuts and herbs. Previous studies have demonstrated that myricetin exhibits anti-cancer activity against several tumor types. However, an anti-cancer effect of myricetin against human papillary thyroid cancer (HPTC) cells has not been established. The present investigation was undertaken to gain insights into the molecular mechanism of the anti-cancer activity of myricetin against HPTC cells. We examined the cytotoxicity, DNA damaging, and cell cycle arresting activities of myricetin using SNU-790 HPTC cells. We found that myricetin exhibited cytotoxicity and induced DNA condensation in SNU-790 HPTC cells in a dose-dependent manner. Moreover, myricetin up-regulated the activation of caspase cascades and the Bax:Bcl-2 expression ratio. In addition, myricetin induced the release of apoptosis-inducing factor (AIF) and altered the mitochondrial membrane potential. Our results suggest that myricetin induces the death of SNU-790 HPTC cells and thus may prove useful in the development of therapeutic agents for human thyroid cancers. |
| Databáze: | OpenAIRE |
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