Modulation of pentylenetetrazol-induced seizure activity by branched-chain amino acids and α-ketoisocaproate
| Autor: | Katarzyna A. Nałęcz, Astrid Nehlig, Franck Dufour, Maciej J. Nałęcz |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Branched-chain amino acid Biology chemistry.chemical_compound Seizures Valine Internal medicine Reaction Time medicine Animals Rats Wistar Pentylenetetrazol Caproates Molecular Biology Injections Intraventricular chemistry.chemical_classification General Neuroscience Glutamate receptor Electroencephalography medicine.disease Keto Acids Rats Amino acid Absence seizure Endocrinology chemistry Biochemistry Pentylenetetrazole Neurology (clinical) Leucine Isoleucine Amino Acids Branched-Chain Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 815:400-404 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(98)01188-3 |
| Popis: | Branched-chain amino acids, and mainly leucine act as nitrogen donors in the cerebral glutamate-glutamine cycle, thereby reducing brain excitability. Rats equipped with cortical electrodes received 300 mg/kg of leucine, isoleucine, valine or the ketoacid of leucine, alpha-ketoisocaproate at 2 h before the induction of seizures by 40 mg/kg pentylenetetrazol. Control groups received saline or a commercial mixture of amino acids, Vamine(R). Leucine and isoleucine increased the latency to absence-like and tonic-clonic seizures but did not influence the duration of the tonic-clonic seizure. Vamine(R), valine and alpha-ketoisocaproate had no effect. These data are consistent with the role of leucine in buffering brain glutamate concentration. |
| Databáze: | OpenAIRE |
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