Conjugated Coordination Porphyrin-based Nanozymes for Photo-/Sono-Augmented Biocatalytic and Homologous Tumor Treatments
| Autor: | Fangxue Du, Lang Ma, Chong Cheng, Liyun Wang, Jianbo Huang, Luchang Liu, Yuanjiao Tang, Li Qiu, Li Song, Bowen Ke, Ling Li |
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| Rok vydání: | 2021 |
| Předmět: |
Radiation-Sensitizing Agents
Future studies Materials science Porphyrins Light Cell Antineoplastic Agents Conjugated system Catalysis chemistry.chemical_compound Mice In vivo Coordination Complexes Neoplasms Homologous chromosome medicine Human Umbilical Vein Endothelial Cells Animals Humans General Materials Science Tumor microenvironment Hydroxyl Radical Melanoma Cell Membrane medicine.disease Porphyrin Combinatorial chemistry medicine.anatomical_structure chemistry Ultrasonic Waves Nanoparticles |
| Zdroj: | ACS applied materialsinterfaces. 13(35) |
| ISSN: | 1944-8252 |
| Popis: | Porphyrin-based nanozymes (Porzymes) have shown promising application potential to fight against tumors using catalytically generated reactive oxygen species from the excessively produced H2O2 in the tumor microenvironment. However, the low coordination porphyrin (CP) loading ratio, difficult controllable nanostructure, low bioavailability, and low biocatalytic activities of current established Porzymes have severely limited their antitumor applications. Here, a novel malignant melanoma cell membrane-coated Pd-based CP nanoplatform (Trojan Porzymes) has been synthesized for biocatalytic and homologous tumor therapies. The Trojan Porzymes exhibit a high CP loading ratio, uniform nanoscale size, single-atom nanostructure, homologous targeted ability, and high-efficiency photo/sono-augmented biocatalytic activities. The enzyme-like biocatalytic experiments display that the Trojan Porzymes can generate abundant •OH via chemodynamic path and 1O2 via visible light or ultrasound excitation. Then we demonstrate that the Trojan Porzymes show homologous targeting ability to tumor cells and can achieve efficient accumulation and long-term retention in cancer tissues. Our in vivo data further disclose that the photo/sono-assisted chemodynamic therapies can significantly augment the treatment efficiency of malignant melanoma. We believe that our work will afford a new biocatalytic and homologous strategy for future clinical malignant melanoma treatments, which may inspire and guide more future studies to develop individualized biomedicine in precise tumor therapies. |
| Databáze: | OpenAIRE |
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