Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease
| Autor: | Vesna Vucic, Danijela Ristic-Medic, Maja Jovicic, Marijana Kovačić, Snjezana Petrovic, Marija Takić, Marija Paunovic, Aleksandra Arsic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male nonalcoholic fatty liver disease Mediterranean diet fatty liver index HOMA-IR index Diet Mediterranean 0302 clinical medicine Non-alcoholic Fatty Liver Disease Weight loss Nonalcoholic fatty liver disease steatosis Diet Fat-Restricted 2. Zero hunger chemistry.chemical_classification Nutrition and Dietetics Fatty liver 3. Good health Liver Docosahexaenoic acid 030211 gastroenterology & hepatology Waist Circumference medicine.symptom lcsh:Nutrition. Foods and food supply Polyunsaturated fatty acid Adult medicine.medical_specialty 030209 endocrinology & metabolism lcsh:TX341-641 low-fat diet fatty acids Article 03 medical and health sciences Internal medicine medicine Humans Caloric Restriction business.industry Body Weight Cardiometabolic Risk Factors Fatty acid nutritional and metabolic diseases medicine.disease digestive system diseases Endocrinology chemistry Steatosis business Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 15, p 15 (2021) Nutrients Volume 13 Issue 1 |
| ISSN: | 2072-6643 |
| Popis: | Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets&mdash the Mediterranean diet (Med diet) and low-fat diet&mdash on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss (> 9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p < 0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients. |
| Databáze: | OpenAIRE |
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