A case of aggressive myeloma recognized shortly after the remission following high-dose chemotherapy with autologous peripheral blood stem cell transplantation
| Autor: | Hikaru Ishizuka, Umihiko Sawada, Jin Takeuchi, Sumiko Kobayashi, Katsuhiro Miura, Kaname Ueda, Toshitake Tanaka, Yoshimasa Kura, Yoshihiro Hatta, Atsuko Hojo |
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| Rok vydání: | 2009 |
| Předmět: |
Melphalan
medicine.medical_specialty Fever medicine.medical_treatment Chromosome Disorders Transplantation Autologous Dexamethasone Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Autologous transplantation Humans Multiple myeloma Chemotherapy Peripheral Blood Stem Cell Transplantation Hematology Chromosomes Human Pair 13 business.industry Remission Induction Acute Kidney Injury Middle Aged medicine.disease Peripheral stem cell transplantation Surgery Transplantation medicine.anatomical_structure Doxorubicin Vincristine Female Bone marrow Chromosome Deletion business Multiple Myeloma medicine.drug |
| Zdroj: | International journal of hematology. 92(3) |
| ISSN: | 1865-3774 |
| Popis: | A 45-year-old woman was referred to our hospital with acute renal failure and pyrexia. In August 2005, the patient was diagnosed with IgA-λ type multiple myeloma with chromosome 13 deletion, and received three cycles of vinclistine, adriamycin and dexamethasone followed by high-dose melphalan-based autologous peripheral stem cell transplantation: this resulted in remission 2 months before admission to our hospital. Serum IgA concentration was within the normal limit, but an excess of myeloma cells in bone marrow was confirmed. Immunoelectrophoresis revealed BJP-λ production with no IgA-λ. The patient received several courses of chemotherapy with mechanical ventilation and regular hemodialysis. The progression of the illness was rapid: multiple organ failure promptly developed and the patient died 2 months after admission. Autopsy revealed deposition of light chain λ protein in multiple organs. We report this unusual case of aggressive myeloma recognized shortly after successful autologous transplantation. |
| Databáze: | OpenAIRE |
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