Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma

Autor:	Melanie Ruf, Peter Schraml, Holger Moch
Přispěvatelé:	University of Zurich, Ruf, Melanie
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Lymphocyte Immunology Tumor cells 610 Medicine & health chemical and pharmacologic phenomena urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation immune system diseases 10049 Institute of Pathology and Molecular Pathology medicine Immunology and Allergy Gene Author's View 030304 developmental biology CD70 0303 health sciences 2403 Immunology Chemistry virus diseases hemic and immune systems medicine.disease 3. Good health Clear cell renal cell carcinoma medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research 2723 Immunology and Allergy 2730 Oncology Infiltration (medical)
Zdroj:	Oncoimmunology
Popis:	CD70 upregulation by hypoxia-inducible factor and CD27(+) lymphocyte tumor infiltration are associated with worse survival in von Hippel-Lindau gene (VHL) mutated clear cell renal cell carcinoma (ccRCC). CD70/CD27 interaction is accompanied by high soluble CD27 levels in the sera of ccRCC patients suggesting that soluble CD27 is a potential predictive tool for anti-CD70 therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187b825618604ca4e27374f52d256919 https://europepmc.org/articles/PMC4635726/ Zobrazit plný text záznamu