Synthesis, characterization, antifungal and anti-HIV activities of metal(II) complexes of 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol
| Autor: | Oleg I. Shadyro, A.A. Chernyavskaya, Pyotr G. Rytik, N.V. Loginova, T.V. Koval’chuk, G. I. Polozov, N.P. Osipovich, Victor L. Sorokin, Igor I. Kucherov |
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| Rok vydání: | 2007 |
| Předmět: |
Pharmacology
Denticity Antifungal Agents Stereochemistry Ligand Anti-HIV Agents Spectrum Analysis Organic Chemistry Diol Thio General Medicine Medicinal chemistry Chemical synthesis Metal chemistry.chemical_compound chemistry Metals visual_art Drug Discovery visual_art.visual_art_medium Organometallic Compounds Cyclic voltammetry Benzene |
| Zdroj: | European journal of medicinal chemistry. 43(7) |
| ISSN: | 0223-5234 |
| Popis: | Co(II) and Ni(II) complexes with 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol (L) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, ESR, UV–vis, XRD, magnetic susceptibility, cyclic voltammetry and conductance measurements. According to the data obtained the organic compound acts as a bidentate O,S-coordinated ligand and yields Co(II) and Ni(II) complexes of the stoichiometry ML2 which is characterized by square planar geometry. Antifungal and anti-HIV activities of the ligand and its metal(II) complexes were found to decrease in the sequence CuL2 > CoL2 ∼ NiL2 > HL, along with their reducing ability (determined electrochemically). |
| Databáze: | OpenAIRE |
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