Association Between BDNF Val66Met Polymorphism and Alzheimer Disease, Dementia With Lewy Bodies, and Pick Disease
| Autor: | Zoltán Janka, Anna Juhász, Ágnes Rimanóczy, János Kálmán, Ágnes Fehér |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Lewy Body Disease
Male Apolipoprotein E medicine.medical_specialty Genotype Apolipoprotein E4 Neuropsychological Tests Polymerase Chain Reaction behavioral disciplines and activities Degenerative disease Pick Disease of the Brain Alzheimer Disease Risk Factors Internal medicine mental disorders medicine Humans Genetic Predisposition to Disease Allele Brain-derived neurotrophic factor Polymorphism Genetic Dementia with Lewy bodies Brain-Derived Neurotrophic Factor medicine.disease nervous system diseases Psychiatry and Mental health Clinical Psychology Endocrinology nervous system Female lipids (amino acids peptides and proteins) Gene polymorphism Geriatrics and Gerontology Alzheimer's disease Psychology Gerontology Neuroscience |
| Zdroj: | Alzheimer Disease & Associated Disorders. 23:224-228 |
| ISSN: | 0893-0341 |
| Popis: | A functional polymorphism of the brain-derived neurotrophic factor (BDNF Val66Met) has been reported to affect memory-related hippocampal activity. Apolipoprotein E (ApoE) gene polymorphism is known to be associated with Alzheimer disease (AD), dementia with Lewy bodies (DLB), and Pick disease (PiD). We tested the hypothesis that BDNF Val and ApoE epsilon4 alleles confer susceptibility to AD, DLB, and PiD. The study included 160 AD, 34 DLB patients, 38 autopsy-confirmed PiD, and 164 age-matched healthy control (HC) probands. The frequency of the BDNF Val allele was significantly higher in AD, but there were no statistical differences in the allele distribution in PiD or in DLB as compared with HC. The Val/Met genotype occurred with statistically significantly higher frequency in PiD than in HC. The ApoE epsilon4 allele was significantly overrepresented in all dementias as compared with HC. Genotypes containing both ApoE epsilon4 and BDNF Val alleles occurred more frequently in all investigated dementias than in HC. We suggest that the presence of the BDNF Val allele in itself and in combination with the ApoE epsilon4 allele can be risk factors for AD, and the results indicate a synergistic effect of the 2 polymorphisms on DLB and PiD risk. |
| Databáze: | OpenAIRE |
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