Study of fibrotic complications and hydroxyproline content in mouse liver at different stages of generalized BCG-induced granulomatosis
| Autor: | T. V. Sharkova, I. K. Nikonova, V. A. Shkurupii, L. B. Kim, O. V. Potapova, A. N. Putyatina |
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| Rok vydání: | 2013 |
| Předmět: |
Vacuolar degeneration
Liver Cirrhosis Male Pathology medicine.medical_specialty Male mice Inflammation Necrotic Change Biology General Biochemistry Genetics and Molecular Biology Hydroxyproline chemistry.chemical_compound Mice Fibrosis medicine Animals Mice Inbred BALB C Granuloma Macrophages Gastrointestinal pathology General Medicine Fibroblasts medicine.disease chemistry Liver Tuberculosis Gastrointestinal Acute Disease Chronic Disease BCG Vaccine Hepatocytes Collagen medicine.symptom |
| Zdroj: | Bulletin of experimental biology and medicine. 157(4) |
| ISSN: | 1573-8221 |
| Popis: | Generalized BCG-induced granulomatous was simulated in BALB/c male mice. The number of tuberculous granulomas in the liver and their size as well as the number of hepatocytes showing vacuolar degeneration increased from day 3 to 180 postinfection. Necrotic changes in hepatocytes were most pronounced at the acute phase of inflammation (days 3 to 30). Proliferative processes in the liver parenchyma in the experimental group were less marked than in the control. Increased content of collagen fibers in the liver was determined by excessive collagen synthesis in necrotic areas as well as increased amount of granulomas and fibroblasts. Enhanced proliferative and fibroplastic activity of fibroblasts in granulomas and liver parenchyma was evidently determined by activated granuloma macrophages. These shifts determined changes in the liver content of hydroxyproline during the acute and chronic periods of the disease. |
| Databáze: | OpenAIRE |
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