Sensitivity and specificity of the StratusOCT for perimetric glaucoma
Autor: | Joanne Katz, Robert T. Chang, John McSoley, Anika Michael, Donald L. Budenz |
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Rok vydání: | 2005 |
Předmět: |
Adult
Male Retinal Ganglion Cells medicine.medical_specialty genetic structures Eye disease Vision Disorders Nerve fiber layer Glaucoma Diagnostic Techniques Ophthalmological Sensitivity and Specificity chemistry.chemical_compound Nerve Fibers Optical coherence tomography Ophthalmology Humans Medicine Prospective Studies Aged Decibel Aged 80 and over medicine.diagnostic_test Receiver operating characteristic business.industry Reproducibility of Results Retinal Middle Aged medicine.disease eye diseases Visual field Cross-Sectional Studies medicine.anatomical_structure ROC Curve chemistry Visual Field Tests Female sense organs Visual Fields business Tomography Optical Coherence |
Zdroj: | Ophthalmology. 112:3-9 |
ISSN: | 0161-6420 |
DOI: | 10.1016/j.ophtha.2004.06.039 |
Popis: | To determine the sensitivity and specificity of measurements of the retinal nerve fiber layer (RNFL) using the StratusOCT in glaucoma subjects with visual field (VF) defects.Prospective cross-sectional study.One hundred nine normal and 63 glaucoma subjects.Fast RNFL scans were performed in one eye of each patient using the StratusOCT.Sensitivity and specificity of different optical coherence tomography (OCT) criteria for identifying glaucoma subjects with glaucomatous VF defects.Areas under the receiver operating characteristic curves (AROCs) for various OCT parameters.Severity of VF defects in the glaucoma group was distributed between mild (18 subjects), moderate (21 subjects), and severe (24 subjects). The average mean deviation of the glaucoma fields was -8.4 decibels (dB), with a standard deviation of 6.0 dB and a range from -0.14 to -28.0 dB. The sensitivity and specificity using a criterion of average RNFL thickness abnormal at the5% level were 84% and 98%, respectively. The sensitivity and specificity using a criterion of average RNFL thickness abnormal at the1% level were 68% and 100%. The sensitivity and specificity of using a criterion ofor=1 quadrants abnormal at the5% level were 89% and 95%. The sensitivity and specificity of using a criterion ofor=1 quadrants abnormal at the1% level were 83% and 100%. The sensitivity and specificity of using a criterion ofor=1 clock hours abnormal at the5% level were 89% and 92%. The sensitivity and specificity of using a criterion ofor=1 quadrants abnormal at the1% level were 83% and 100%. The AROC for mean RNFL thickness was 0.966. Other high AROC values included the superior quadrant (0.952), inferior quadrant (0.971), inferotemporal clock hour at 7-o'clock (right eye) and 5-o'clock (left eye) (0.959), 6-o'clock hour (0.940), superotemporal clock hour at 11-o'clock (right eye) and 1-o'clock (left eye) (0.935), and 12-o'clock hour (0.924).The sensitivity and specificity of RNFL measurements using the new StratusOCT for glaucoma with manifest VF defects are excellent. The best parameters seem to beor=1 quadrants abnormal at theor=5% level oror=1 clock hours abnormal at theor=5% level. Future studies are needed to determine the sensitivity and specificity of this new technology for glaucoma without VF defects. |
Databáze: | OpenAIRE |
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