Association of sleep duration in middle and old age with incidence of dementia

Autor: Archana Singh-Manoux, Claire Paquet, Séverine Sabia, Andrew Sommerlad, Julien Dumurgier, Vincent T. van Hees, Aline Dugravot, Aurore Fayosse, Mika Kivimäki
Přispěvatelé: Clinicum, University of Helsinki, Epidemiology of Ageing and Neurodegenerative diseases [Paris] (EpiAgeing), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University College of London [London] (UCL), Institut National de la Santé et de la Recherche Médicale (INSERM), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, ANR-19-CE36-0004,ActivHealth,Rôle de l'intensité, de la durée et des profils d'activité physique mesurés par accéléromètres pour la santé cardiométabolique(2019), Université Paris Cité, Equipe HAL, Rôle de l'intensité, de la durée et des profils d'activité physique mesurés par accéléromètres pour la santé cardiométabolique - - ActivHealth2019 - ANR-19-CE36-0004 - AAPG2019 - VALID
Rok vydání: 2021
Předmět:
Male
Pediatrics
Longitudinal study
Time Factors
Epidemiology
proportional hazards model
very elderly
General Physics and Astronomy
3124 Neurology and psychiatry
Cohort Studies
0302 clinical medicine
cardiometabolic risk
time factor
Longitudinal Studies
030212 general & internal medicine
DISTURBANCE
sleep disorder
Aged
80 and over
RISK
Multidisciplinary
sleep time
Incidence
Incidence (epidemiology)
Hazard ratio
longitudinal study
Age Factors
Middle Aged
IMPAIRMENT
cohort analysis
Sleep in non-human animals
ALZHEIMERS-DISEASE
risk factor
Female
mental health
Cohort study
Adult
Sleep Wake Disorders
medicine.medical_specialty
Science
complication
Article
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
mental disorders
medicine
[SDV.EE.SANT] Life Sciences [q-bio]/Ecology
environment/Health
Humans
Dementia
controlled study
Aged
Proportional Hazards Models
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology
environment/Health
Proportional hazards model
business.industry
disease association
3112 Neurosciences
General Chemistry
medicine.disease
major clinical study
United Kingdom
Risk factors
physiology
Sleep Deprivation
Sleep
business
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, 2021, 12 (1), pp.2289. ⟨10.1038/s41467-021-22354-2⟩
ISSN: 2041-1723
Popis: Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, we examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up. Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (7 h) sleep duration, although this was imprecisely estimated for sleep duration at age 70 (hazard ratios (HR) 1.22 (95% confidence interval 1.01–1.48), 1.37 (1.10–1.72), and 1.24 (0.98–1.57), respectively). Persistent short sleep duration at age 50, 60, and 70 compared to persistent normal sleep duration was also associated with a 30% increased dementia risk independently of sociodemographic, behavioural, cardiometabolic, and mental health factors. These findings suggest that short sleep duration in midlife is associated with an increased risk of late-onset dementia.
Sleep dysregulation has been linked to dementia, but it is unknown whether sleep duration earlier in life is associated with dementia risk. Here, the authors show higher dementia risk associated with short sleep duration (six hours or less) in a longitudinal study of middle and older age adults.
Databáze: OpenAIRE
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