Association of sleep duration in middle and old age with incidence of dementia
Autor: | Archana Singh-Manoux, Claire Paquet, Séverine Sabia, Andrew Sommerlad, Julien Dumurgier, Vincent T. van Hees, Aline Dugravot, Aurore Fayosse, Mika Kivimäki |
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Přispěvatelé: | Clinicum, University of Helsinki, Epidemiology of Ageing and Neurodegenerative diseases [Paris] (EpiAgeing), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University College of London [London] (UCL), Institut National de la Santé et de la Recherche Médicale (INSERM), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, ANR-19-CE36-0004,ActivHealth,Rôle de l'intensité, de la durée et des profils d'activité physique mesurés par accéléromètres pour la santé cardiométabolique(2019), Université Paris Cité, Equipe HAL, Rôle de l'intensité, de la durée et des profils d'activité physique mesurés par accéléromètres pour la santé cardiométabolique - - ActivHealth2019 - ANR-19-CE36-0004 - AAPG2019 - VALID |
Rok vydání: | 2021 |
Předmět: |
Male
Pediatrics Longitudinal study Time Factors Epidemiology proportional hazards model very elderly General Physics and Astronomy 3124 Neurology and psychiatry Cohort Studies 0302 clinical medicine cardiometabolic risk time factor Longitudinal Studies 030212 general & internal medicine DISTURBANCE sleep disorder Aged 80 and over RISK Multidisciplinary sleep time Incidence Incidence (epidemiology) Hazard ratio longitudinal study Age Factors Middle Aged IMPAIRMENT cohort analysis Sleep in non-human animals ALZHEIMERS-DISEASE risk factor Female mental health Cohort study Adult Sleep Wake Disorders medicine.medical_specialty Science complication Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences mental disorders medicine [SDV.EE.SANT] Life Sciences [q-bio]/Ecology environment/Health Humans Dementia controlled study Aged Proportional Hazards Models [SDV.EE.SANT]Life Sciences [q-bio]/Ecology environment/Health Proportional hazards model business.industry disease association 3112 Neurosciences General Chemistry medicine.disease major clinical study United Kingdom Risk factors physiology Sleep Deprivation Sleep business 030217 neurology & neurosurgery Follow-Up Studies |
Zdroj: | Nature Communications Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021) Nature Communications, 2021, 12 (1), pp.2289. ⟨10.1038/s41467-021-22354-2⟩ |
ISSN: | 2041-1723 |
Popis: | Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, we examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up. Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (7 h) sleep duration, although this was imprecisely estimated for sleep duration at age 70 (hazard ratios (HR) 1.22 (95% confidence interval 1.01–1.48), 1.37 (1.10–1.72), and 1.24 (0.98–1.57), respectively). Persistent short sleep duration at age 50, 60, and 70 compared to persistent normal sleep duration was also associated with a 30% increased dementia risk independently of sociodemographic, behavioural, cardiometabolic, and mental health factors. These findings suggest that short sleep duration in midlife is associated with an increased risk of late-onset dementia. Sleep dysregulation has been linked to dementia, but it is unknown whether sleep duration earlier in life is associated with dementia risk. Here, the authors show higher dementia risk associated with short sleep duration (six hours or less) in a longitudinal study of middle and older age adults. |
Databáze: | OpenAIRE |
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