Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant
| Autor: | Ivar Eide, Trond Jenssen, Willy Aasebø, My Svensson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Short form 36 Gastroenterology Kidney transplant law.invention Randomized controlled trial Quality of life law Internal medicine Surveys and Questionnaires Fatty Acids Omega-3 medicine Humans VDP::Medisinske Fag: 700 Aged chemistry.chemical_classification Transplantation business.industry Middle Aged Kidney Transplantation Post transplant Transplant Recipients VDP::Medical disciplines: 700 Polyunsaturated fatty acid supplementation chemistry Renal transplant Dietary Supplements Quality of Life Surgery Female business Polyunsaturated fatty acid |
| ISSN: | 0041-1345 |
| Popis: | Accepted manuscript version, licensed CC BY-NC-ND 4.0. Marine n-3 polyunsaturated fatty acids (PUFAs) may improve cardiovascular, renal, and mental health. No previous trial has investigated the effects of marine n-3 PUFA supplementation on quality of life (QoL) indices after renal transplant. Methods - In this trial, 132 renal transplant recipients were randomized to receive daily either 2.6 g of marine n-3 PUFAs or an equivalent dose of olive oil (controls) on top of standard care for 44 weeks. We used a Short Form 36 (SF-36) questionnaire at baseline (8 weeks post transplant) and at the end of the study (1 year after transplant) to assess QoL. Results were expressed as net change (Δ) in SF-36 individual and composite mental and physical scores during follow-up. Results - We found no improvement of Δ SF-36 individual or composite scores after marine n-3 PUFA supplementation compared with controls. In per-protocol analysis, patients who received marine n-3 PUFAs had a Δ emotional role function (mean, 17% [SD, 50%] vs mean, 3% [SD, 37%]; P = .11). In addition, plasma marine n-3 PUFA levels showed a weak but statistically significant correlation with Δ composite mental function score (r = .18; P = .04). Conclusion - Marine n-3 PUFA supplementation did not improve QoL after renal transplant. |
| Databáze: | OpenAIRE |
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