In utero and lactational exposure to fipronil in female rats: Pregnancy outcomes and sexual development
| Autor: | Aline Lima de Barros, Patrícia Villela e Silva, Cibele dos Santos Borges, Josiane de Lima Rosa, Arielle Cristina Arena, Julie Heejoo Bae, Janete Aparecida Anselmo-Franci, Marilia Martins Cavariani |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP) |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Insecticides Health Toxicology and Mutagenesis Physiology Ovary 010501 environmental sciences Biology Female reproductive system Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Sexual Behavior Animal Estrus Pregnancy Internal medicine medicine Animals Lactation Rats Wistar Gonadal Steroid Hormones Fipronil 0105 earth and related environmental sciences Estrous cycle Perinatal Exposure Sexual Development Anogenital distance Uterus Pregnancy Outcome medicine.disease Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Fertility chemistry Prenatal Exposure Delayed Effects Vagina Gestation Pyrazoles Female |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1528-7394 |
| Popis: | Made available in DSpace on 2018-12-11T17:02:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-03-18 Fipronil, a phenylpyrazole insecticide, is used in agriculture, veterinary medicine, and public health. Because this insecticide is considered a potential endocrine disruptor, the aim of this study was to examine the influence of perinatal exposure to fipronil on neonatal female reproductive system development. Pregnant rats were exposed (via gavage) daily to fipronil (0.03, 0.3, or 3 mg/kg) from gestational day 15 to day 7 after birth, and effects on the reproductive functions assessed on postnatal day (PND) 22. No signs of maternal toxicity were observed during daily treatment with fipronil. Perinatal exposure to the highest dose of fipronil (3 mg/kg) delayed the age of vaginal opening (VO) and first estrus without markedly affecting the anogenital distance (AGD). Further, exposure to 0.3 mg/kg fipronil produced a significantly shorter estrus cycle and reduced number of cycles during the period of evaluation. However, the other reproductive parameters analyzed, including fertility, hormone levels, sexual behavior, and histology of ovaries and uterus, displayed no marked alterations. In this experimental model, fipronil interfered with development of neonatal female reproductive system as evidenced by delay in VO and estrus cycle alterations without apparent significant effects on fertility. Further studies are needed to identify the mechanisms of action associated with the observed female reproductive system changes. Department of Morphology Institute of Biosciences of Botucatu Univ Estadual Paulista (UNESP)-Botucatu Distrito de Rubião Junior, s/n, Caixa Postal-510 Department of Physiology Ribeirão Preto Medical School University of São Paulo (USP) Department of Morphology Institute of Biosciences of Botucatu Univ Estadual Paulista (UNESP)-Botucatu Distrito de Rubião Junior, s/n, Caixa Postal-510 |
| Databáze: | OpenAIRE |
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