A ‘chemical help’ in middle-ear surgery? A systematic review on sodium 2-mercaptoethanesulfonate
| Autor: | Antonio Moffa, Manuele Casale, Valeria Fiore, M Tarabichi, Vittorio Rinaldi, Michele Cassano, M Kapadia, Lorenzo Sabatino |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Ear Middle Mastoidectomy Atelectasis Protective Agents 03 medical and health sciences 0302 clinical medicine Ototoxicity otorhinolaryngologic diseases medicine Humans 030223 otorhinolaryngology Mesna Cholesteatoma Middle Ear medicine.diagnostic_test business.industry Cholesteatoma Retrospective cohort study General Medicine Tympanoplasty medicine.disease Endoscopy Surgery Otitis Media Otorhinolaryngology business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Journal of Laryngology & Otology. 135:660-667 |
| ISSN: | 1748-5460 0022-2151 |
| Popis: | ObjectiveSodium 2-mercaptoethanesulfonate (Mesna) has been proposed as a chemical aid in any surgical procedure, including cholesteatoma surgery. This review investigated the benefits and safety of Mesna during surgical management of cholesteatoma and adhesive otitis media.MethodA systematic literature review was performed to identify clinical studies evaluating topical Mesna application during ear surgery (cholesteatoma or atelectasis). A qualitative analysis based on data extracted was conducted.ResultsFrom 27 articles, 5 retrospective studies were selected for a full analysis for a total of 607 patients (aged 5 to 72 years). Three studies evaluated cholesteatoma recidivism after Mesna application during cholesteatoma surgery, one study evaluated the surgical success rate of Mesna application for the treatment of atelectatic ears and adhesive otitis media, and one study evaluated potential ototoxicity of Mesna during cholesteatoma surgery. All the studies showed overall improvement in recurrence and residual cholesteatoma disease after Mesna application during surgery. Sensorineural hearing loss was not encountered after Mesna application.ConclusionMesna application in cholesteatoma surgery could represent a valid and safe support tool during surgical treatment carried out both with microscopy and endoscopy. More studies are required to confirm these promising results. |
| Databáze: | OpenAIRE |
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