An injectable photothermally active antibacterial composite hydroxypropyl chitin hydrogel for promoting the wound healing process through photobiomodulation
| Autor: | Xulin Jiang, Yalan Zhong, Mengsi Ma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Wound Healing
integumentary system Regeneration (biology) Composite number Biomedical Engineering Chitin Hydrogels macromolecular substances General Chemistry General Medicine Photothermal therapy Anti-Bacterial Agents chemistry.chemical_compound chemistry In vivo Tannic acid General Materials Science Low-Level Light Therapy Wound healing Antibacterial agent Biomedical engineering |
| Zdroj: | Journal of Materials Chemistry B. 9:4567-4576 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/d1tb00724f |
| Popis: | Prevention of bacterial infection, acceleration of wound closure and promotion of skin regeneration are crucial in the wound healing process. In this work, the photothermal activity of an injectable thermosensitive composite hydrogel based on hydroxypropyl chitin (HPCH), tannic acid (TA) and ferric ions (Fe3+) was studied. It was found that the photothermal efficiency was enhanced when the molar ratio of Fe3+/TA increased up to 20. The composite hydrogel possessed good cytocompatibility and hemocompatibility with a low dosage of the antibacterial agent TA. In vitro and in vivo antibacterial tests showed that the HPCH/TA/Fe hydrogel possessed an effective and rapid bactericidal effect with 10 minutes of near-infrared laser irradiation. Furthermore, the combination of a low-level laser therapy with the hydrogel is conducive to the acceleration of wound closure and promotion of skin tissue repair. Thus, the injectable photothermally active antibacterial composite hydrogel has great potential for the infected skin wound regeneration in clinical applications. |
| Databáze: | OpenAIRE |
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