Interference with gesture production by theta burst stimulation over left inferior frontal cortex
| Autor: | Manuel Bertschi, Christian W. Hess, Pascal Wurtz, René M. Müri, Dario Cazzoli, Thomas Nyffeler, Stephan Bohlhalter, Tim Vanbellingen |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors CTBS Neurological disorder Audiology Apraxia Biophysical Phenomena 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Neuroimaging Physiology (medical) Reaction Time medicine Humans 0501 psychology and cognitive sciences Dominance Cerebral Analysis of Variance Brain Mapping Gestures 05 social sciences Repeated measures design Electroencephalography Inferior parietal lobule medicine.disease Electric Stimulation Sensory Systems Frontal Lobe Forearm Neurology Frontal lobe Female Neurology (clinical) Psychology Neuroscience Psychomotor Performance 030217 neurology & neurosurgery Gesture |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiol |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2010.11.008 |
| Popis: | Objective The traditional view of a predominant inferior parietal representation of gestures has been recently challenged by neuroimaging studies demonstrating that gesture production and discrimination may critically depend on inferior frontal lobe function. The aim of the present work was therefore to investigate the effect of transient disruption of these brain sites by continuous theta burst stimulation (cTBS) on gesture production and recognition. Methods Fourteen healthy subjects participated in the study. A repeated measures design was employed with three experimental sessions: baseline (BSL), left inferior parietal (IPL) and inferior frontal (IFG) TBS. Gesture production and recognition was assessed in an off-line approach using a new test of upper limb apraxia (TULIA) and a modified version of postural knowledge test (PKT). Results TBS of the left IFG significantly lowered total TULIA scores. The effect was even more prominent when contrasted with IPL than with BSL. However, TBS over either stimulation site did not significantly influence PKT measures. Conclusions The interference of the left inferior frontal cTBS with gesture production emphasizes the role this brain region has in the control of gestures. Significance The study demonstrated that gesture performance is amenable to modulation with TBS. |
| Databáze: | OpenAIRE |
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