Synergistic Benefits of Combined Aerobic and Cognitive Training on Fluid Intelligence and the Role of IGF-1 in Chronic Stroke
| Autor: | Augustine Joshua Devasahayam, S. M. Mahmudul Hasan, Graham Wilson, Matthew B. Downer, Emily Bedford, Beraki Abraha, Arthur R. Chaves, Laura Keeler, Craig S. Moore, Gail A. Eskes, Marie E Curtis, Jason McCarthy, Elaine Skene, Michelle Ploughman, Liam P. Kelly, Elizabeth M. Wallack, Ishika Sharma, George S. Robertson, Megan C. Kirkland, Marilyn MacKay-Lyons |
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| Rok vydání: | 2019 |
| Předmět: |
Male
030506 rehabilitation medicine.medical_treatment Intelligence law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Neuroplasticity Medicine Humans Insulin-Like Growth Factor I Aged Brain-derived neurotrophic factor Rehabilitation biology Cognitive Behavioral Therapy business.industry Stroke Rehabilitation Cognition General Medicine Middle Aged Combined Modality Therapy Cognitive training Exercise Therapy Stroke Treatment Outcome Chronic Disease biology.protein Female 0305 other medical science business Priming (psychology) Neuroscience 030217 neurology & neurosurgery Neurotrophin |
| Zdroj: | Neurorehabilitation and neural repair. 33(3) |
| ISSN: | 1552-6844 |
| Popis: | Background. Paired exercise and cognitive training have the potential to enhance cognition by “priming” the brain and upregulating neurotrophins. Methods. Two-site randomized controlled trial. Fifty-two patients >6 months poststroke with concerns about cognitive impairment trained 50 to 70 minutes, 3× week for 10 weeks with 12-week follow-up. Participants were randomized to 1 of 2 physical interventions: Aerobic (>60% VO2peak using resting) and after a graded exercise test (BDNFresponse) and insulin-like growth factor–1 at the same timepoints (IGF-1rest, IGF-1response). Results. At follow-up, fluid intelligence scores significantly improved compared to baseline in the Aerobic + COG and Activity + COG groups; however, only the Aerobic + COG group was significantly different (+47.8%) from control (Activity + Games −8.5%). Greater IGF-1response at baseline predicted 40% of the variance in cognitive improvement. There was no effect of the interventions on BDNFresting or BDNFresponse; nor was BDNF predictive of the outcome. Conclusions. Aerobic exercise combined with cognitive training improved fluid intelligence by almost 50% in patients >6 months poststroke. Participants with more robust improvements in cognition were able to upregulate higher levels of serum IGF-1 suggesting that this neurotrophin may be involved in behaviorally induced plasticity. |
| Databáze: | OpenAIRE |
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