Fertility among female hodgkin lymphoma survivors attempting pregnancy following ABVD chemotherapy

Autor: Michael Crump, Carol-Ann Buckley, Woodrow Wells, Melania Pintilie, Beth DeWitt, Leah Gitterman, Alexander Sun, David C. Hodgson, Katherine Smith, Richard W. Tsang, Sameera Ahmed, Mary Gospodarowicz, Amanda Schwartz
Rok vydání: 2007
Předmět:
Zdroj: Hematological Oncology. 25:11-15
ISSN: 1099-1069
0278-0232
Popis: Although ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) chemotherapy is infrequently associated with premature amenorrhea, little is known about the success rate of women attempting pregnancy following ABVD. In the present study females treated for HL with ABVD chemotherapy without pelvic radiation therapy (RT) and who were alive without relapseor =3 years after treatment were identified from a clinical database and screened for inclusion. Using a standardized questionnaire, we determined the pregnancy rate (i.e. time-to-pregnancy, TTP) among survivors who had become pregnant, tried to become pregnant, or who had been sexually active for over 2 months without using contraception at any time following ABVD. The cumulative incidence of pregnancy was calculated using the Kaplan-Meier method. Cox proportional hazards models were constructed to compare the pregnancy rate among HL survivors to that reported by friend or sibling controls. Thirty-six female HL survivors, who had attempted pregnancy after ABVD treatment, and 29 controls, completed the survey. Eighteen patients (50%) received 2-4 cycles of ABVD, 16 (44%) received 4-6 cycles, and 2 (6%) received6 cycles. The median TTP among both HL survivors and controls was 2.0 months. The 12-month pregnancy rates were 70% and 75%, respectively. The fertility ratio (FR) for HL survivors versus controls was 0.94 (95%CI = 0.53-1.66; p = 0.84) after adjusting for age and frequency of intercourse (where FR1 indicates subfertility). Age at treatment and the number of cycles of chemotherapy were not associated with pregnancy rate among HL survivors. Female HL patients who had survived without recurrenceor =3 years and who had attempted pregnancy after ABVD did not experience significant sub-fertility.
Databáze: OpenAIRE
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