Total ghrelin levels during acute insulin infusion in patients with polycystic ovary syndrome
| Autor: | Mićić J, Natasa Milic, Goran Cvijovic, Felipe F. Casanueva, D. Pejkovic, Aleksandra Kendereski, Carlos Dieguez, M. Sumarac-Dumanovic, Dragan Micic, Svetlana Zoric |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Overweight Body Mass Index Endocrinology Insulin resistance Internal medicine Hyperinsulinism Sex Hormone-Binding Globulin medicine Hyperinsulinemia Humans Hypoglycemic Agents Insulin Testosterone Obesity 2. Zero hunger business.industry digestive oral and skin physiology nutritional and metabolic diseases Fasting Glucose clamp technique medicine.disease Polycystic ovary Ghrelin 3. Good health Acute Disease Glucose Clamp Technique Female medicine.symptom Insulin Resistance business hormones hormone substitutes and hormone antagonists Polycystic Ovary Syndrome |
| Zdroj: | Journal of endocrinological investigation. 30(10) |
| ISSN: | 1720-8386 |
| Popis: | Controversial data were reported concerning fasting ghrelin (decreased, normal or elevated) in polycystic ovary syndrome (PCOS). The aim of our study was to clarify ghrelin levels in non-obese, overweight, and obese PCOS patients; to investigate the effect of acute insulin infusion on ghrelin in PCOS as a chronic insulin-resistant state, with and without the impact of obesity, and to examine ghrelin-androgen interaction. In that order, we evaluated 1) ghrelin levels among 8 nonobese patients with PCOS [body mass index (BMI): 20.52+/-1.31 kg/m2], 8 overweight and obese patients with PCOS (BMI: 34.36+/-6.53 kg/m2) and their respective controls, 2) ghrelin suppression during euglycemic hyperinsulinemic clamp, and 3) ghrelin-androgen interrelationship. After overnight fast, 2-h euglycemic hyperinsulinemic clamp, was performed in all investigated women. Fasting ghrelin was significantly lower in non-obese PCOS than in controls (64.74+/-25.69 vs 108.36+/-52.60; p |
| Databáze: | OpenAIRE |
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