Phase-Variable Expression of lptA Modulates the Resistance of Neisseria gonorrhoeae to Cationic Antimicrobial Peptides
| Autor: | William M. Shafer, Ann E. Jerse, Vijaya Dhulipala, Jacqueline T. Balthazar, Sandeep J. Joseph, Justin L. Kandler, Timothy D. Read |
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| Rok vydání: | 2014 |
| Předmět: |
Operon
Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Lipid A Antibiotic resistance Mechanisms of Resistance Drug Resistance Bacterial medicine Transferase Pharmacology (medical) Gene Pharmacology Mutation Base Sequence food and beverages Ethanolaminephosphotransferase Neisseria gonorrhoeae Anti-Bacterial Agents Infectious Diseases Biochemistry Ethanolamines Polynucleotide Antimicrobial Cationic Peptides |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 58:4230-4233 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.03108-14 |
| Popis: | Phosphoethanolamine (PEA) decoration of lipid A produced by Neisseria gonorrhoeae has been linked to bacterial resistance to cationic antimicrobial peptides/proteins (CAMPs) and in vivo fitness during experimental infection. We now report that the lptA gene, which encodes the PEA transferase responsible for this decoration, is in an operon and that high-frequency mutation in a polynucleotide repeat within lptA can influence gonococcal resistance to CAMPs. |
| Databáze: | OpenAIRE |
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