A prospective trial of young red cells in 48 patients with transfusion-dependent thalassaemia
| Autor: | Beatrix Wonke, E.S. Parry, H. M. Bantock, H. Taite, R. E. Marcus, M.J.G. Thomas, E. R. Huehns |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Cell washer Pediatrics medicine.medical_specialty Adolescent Population Ultrafiltration Hemoglobins Internal medicine Freezing Medicine Humans Blood Transfusion Prospective Studies education Child Whole blood education.field_of_study Thalassaemia major business.industry Infant Transfusion Reaction Hematology Blood Prospective trial Child Preschool Transfusion dependence Thalassemia business Erythrocyte Transfusion |
| Zdroj: | British journal of haematology. 60(1) |
| ISSN: | 0007-1048 |
| Popis: | Summary Young red cells (YRBC) prepared on a cell washer were compared to whole blood in a randomized prospective trial in 48 transfusion dependent patients with thalassaemia major. A minor but statistically significant decrease in blood consumption was observed in the group receiving YRBC. However, no difference was seen in transfusion interval, mean haemoglobin and rate of haemoglobin fall between the two groups. Filtered blood was shown to be as effective as frozen blood in eliminating non-haemolytic febrile transfusion reactions in all the trial patients. We conclude that any reduction in the rate of iron loading brought about by the use of YRBC is clinically insignificant and does not justify the expense, time and work required to produce young red cells for use in a large transfusion dependent thalassaemic population. |
| Databáze: | OpenAIRE |
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