Induced hyperlipaemia and immune challenge in locusts
| Autor: | Graham J. Goldsworthy, Mary E. Lightfoot, Lisa Mullen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Lipopolysaccharide Physiology Fat Body chemical and pharmacologic phenomena Endogeny Enzyme-Linked Immunosorbent Assay Hyperlipidemias Grasshoppers Biology bcs complex mixtures chemistry.chemical_compound Laminarin Immune system Polysaccharides Internal medicine Hemolymph medicine Animals Adipokinetic hormone Glucans Oligopeptide Monophenol Monooxygenase Lipids In vitro Pyrrolidonecarboxylic Acid Lipoproteins LDL Endocrinology Apolipoproteins chemistry Insect Science Insect Hormones Oligopeptides |
| Zdroj: | Journal of insect physiology. 50(5) |
| ISSN: | 0022-1910 |
| Popis: | Injections of immunogens, such as beta-1,3-glucan or lipopolysaccharide (LPS), bring about a marked hyperlipaemia with associated changes in lipophorins and apolipophorin-III in the haemolymph of Locusta migratoria. These changes are similar to those observed after injection of adipokinetic hormone (AKH). The possibility that endogenous AKH is released as part of the response to these immunogens is investigated using passive immunisation against AKH-I, and measurement of AKH-I titre in the haemolymph after injection of immunogens. The data presented show that, despite the similarity of the changes brought about by the presence of immunogens in the haemolymph to those brought about by AKH, there is no release of endogenous AKH after injection of laminarin or LPS. A direct effect of the immunogens on release of neutral lipids by the fat body cannot be demonstrated in vitro, and the mechanism by which hyperlipaemia is induced during immune challenge remains uncertain. |
| Databáze: | OpenAIRE |
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