Increased connectivity of pain matrix in chronic migraine: a resting-state functional MRI study
Autor: | Bo-yong Park, Chin-Sang Chung, Soohyun Cho, Hyunjin Park, Sung Tae Kim, Mi Ji Lee |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
Male medicine.medical_specialty Neurology Migraine Disorders lcsh:Medicine Neuroimaging Anxiety Young Adult 03 medical and health sciences 0302 clinical medicine Chronic Migraine Internal medicine medicine Humans Ictal 030212 general & internal medicine Depression (differential diagnoses) Migraine Chronic migraine Functional MRI Resting state fMRI Depression business.industry lcsh:R Brain General Medicine Middle Aged Pain matrix medicine.disease Magnetic Resonance Imaging Migraine with aura Anesthesiology and Pain Medicine Allodynia Cardiology Female Neurology (clinical) Chronic Pain Nerve Net medicine.symptom business 030217 neurology & neurosurgery Research Article |
Zdroj: | The Journal of Headache and Pain, Vol 20, Iss 1, Pp 1-10 (2019) The Journal of Headache and Pain |
ISSN: | 1129-2377 1129-2369 |
Popis: | Objective To investigate the whole-brain resting-state functional connectivity in patients with chronic migraine (CM) using a data-driven method. Methods We prospectively recruited patients with either episodic migraine (EM) or CM aged 18–60 years who visited the headache clinic of the Samsung Medical Center from July 2016 to December 2017. All patients underwent 3 T MRI using an identical scanner. Patients were considered interictal if they did not have a migraine headache at the day and ± 1 days of functional MRI acquisition. Using the group-independent component analysis (ICA), connectivity analysis with a weighted and undirected network model was performed. The between-group differences in degree centrality (DC) values were assessed using 5000 permutation tests corrected with false discovery rate (FDR). Results A total of 62 patients (44 EM and 18 CM) were enrolled in this study. Among the seven functionally interpretable spatially independent components (ICs) identified, only one IC, interpreted as the pain matrix, showed a significant between-group difference in DC (CM > EM, p = 0.046). This association remained significant after adjustment for age, sex, migraine with aura (MWA), allodynia, depression, and anxiety (p = 0.038). The pain matrix was functionally correlated with the hypothalamus (p = 0.040, EM > CM) and dorsal raphe nucleus (p = 0.039, CM > EM) with different levels of strength in EM and CM. Conclusion CM patients have a stronger connectivity in the pain matrix than do EM patients. Functional alteration of the pain network might play a role in migraine chronification. |
Databáze: | OpenAIRE |
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