Alpha-amylase as molecular target for treatment of diabetes mellitus: A comprehensive review
| Autor: | Vanktesh Kumar, Surendra Kumar Nayak, Paranjit Kaur, Pankaj Wadhwa, Sanjeev Kumar Sahu, Navjot Kaur |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
1-Deoxynojirimycin Indoles Pharmacology Biochemistry chemistry.chemical_compound Structure-Activity Relationship Voglibose Spiroindolone Drug Discovery medicine Diabetes Mellitus Humans Hypoglycemic Agents Glycoside Hydrolase Inhibitors Acarbose Benzofurans chemistry.chemical_classification Flavonoids Oxadiazoles biology Miglitol Organic Chemistry Hydrazones Maltose Enzyme Postprandial chemistry biology.protein Molecular Medicine alpha-Amylases Alpha-amylase Inositol medicine.drug |
| Zdroj: | Chemical biologydrug designREFERENCES. 98(4) |
| ISSN: | 1747-0285 |
| Popis: | The alpha (α)-amylase is a calcium metalloenzyme that aids digestion by breaking down polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the enzyme causes postprandial hyperglycaemia and blood glucose levels to rise. α-Amylase is a well-known therapeutic target for the treatment and maintenance of postprandial blood glucose elevations. Various enzymatic inhibitors, such as acarbose, miglitol and voglibose, have been found to be effective in targeting this enzyme, prompting researchers to express an interest in developing potent alpha-amylase inhibitor molecules. The review mainly focused on designing different derivatives of drug molecules such as benzofuran hydrazone, indole hydrazone, spiroindolone, benzotriazoles, 1,3-diaryl-3-(arylamino) propan-1-one, oxadiazole and flavonoids along with their target-receptor interactions, IC50 values and other biological activities. |
| Databáze: | OpenAIRE |
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