Differential effect of hypobaric hypoxia on potency of CNS depressants in rats and mice
| Autor: | John J. DeFeo, Irwin Baumel, Harbans Lal |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Central Nervous System
Male medicine.drug_class Chloral hydrate Barbital Pharmacology General Biochemistry Genetics and Molecular Biology Body Temperature Mice Species Specificity medicine Potency Animals Chloral Hydrate Hypoxia Pentobarbital Training grant Chemistry Hypothermia Rats Oxygen Atmospheric Pressure Anesthesia Barbiturates Cns depressants Depressant Hypobaric hypoxia medicine.symptom Sleep Injections Intraperitoneal medicine.drug |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 132(2) |
| ISSN: | 0037-9727 |
| Popis: | SummaryAcute exposure of mice and rats to hypobaric hypoxia (364 mm Hg, 10% O2) enhanced the depressant effects of sodium barbital, sodium pentobarbital, and chloral hydrate. Mice were far more sensitive than rats, barbital hypnosis being affected to the greatest extent. In addition, hypothermia observed under the hypobaric environment was greater in mice than in rats.This investigation was supported by PHS Training Grant No. 1T01ES 00104 from the Division of Environmental Health Sciences. |
| Databáze: | OpenAIRE |
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