Fifty Hertz electromagnetic field exposure stimulates secretion of β-amyloid peptide in cultured human neuroglioma
| Autor: | Tullio A. Minelli, Giuliano Moschini, Fabrizio Facchinetti, Alberta Leon, Elda Del Giudice, Valentina Nofrate, Mauro Dam, P. Boccaccio |
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| Rok vydání: | 2007 |
| Předmět: |
Gene isoform
medicine.medical_specialty animal structures Cell Survival Peptide Biology Electromagnetic Fields Alzheimer Disease Cell Line Tumor Occupational Exposure Internal medicine mental disorders medicine Amyloid precursor protein Humans Secretion chemistry.chemical_classification Amyloid beta-Peptides Radiation Brain Neoplasms General Neuroscience Glioma medicine.disease In vitro medicine.anatomical_structure Endocrinology chemistry Cell culture Immunology biology.protein Neuron Alzheimer's disease |
| Zdroj: | Neuroscience Letters. 418:9-12 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2007.02.057 |
| Popis: | Recent epidemiological studies raise the possibility that individuals with occupational exposure to low frequency (50-60 Hz) electromagnetic fields (LF-EMF), are at increased risk of Alzheimer's disease (AD). However, the mechanisms through which LF-EMF may affect AD pathology are unknown. We here tested the hypothesis that the exposure to LF-EMF may affect amyloidogenic processes. We examined the effect of exposure to 3.1 mT 50 Hz LF-EMF on Abeta secretion in H4 neuroglioma cells stably overexpressing human mutant amyloid precursor protein. We found that overnight exposure to LF-EMF induces a significant increase of amyloid-beta peptide (Abeta) secretion, including the isoform Abeta 1-42, without affecting cell survival. These findings show for the first time that exposure to LF-EMF stimulates Abeta secretion in vitro, thus alluding to a potential link between LF-EMF exposure and APP processing in the brain. |
| Databáze: | OpenAIRE |
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