Nonspecific early protective immunity in Francisella and Listeria infections can be dependent on lymphocytes
| Autor: | Ann T. MacIntyre, Tonya R. Rhinehart-Jones, Karen L. Elkins |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Immunology Heterologous Mice SCID Listeria infection Microbiology Tularemia Mice Immunity medicine Animals Listeriosis Lymphocytes Francisella tularensis Mice Inbred BALB C Innate immune system biology medicine.disease biology.organism_classification Immunity Innate Mice Inbred C57BL Infectious Diseases Microbial Immunity and Vaccines Listeria Francisella Parasitology |
| Zdroj: | Infection and immunity. 66(7) |
| ISSN: | 0019-9567 |
| Popis: | Normal mice, but not lymphocyte-deficient or B-cell-deficient mice, given a sublethal infection of Francisella tularensis LVS survive a secondary lethal challenge of more than 10,000 50% lethal doses given 3 days later. In this work, we show that similar early protection that is also strongly lymphocyte dependent operates in Listeria monocytogenes infection. Since sublethal infection with either LVS or L. monocytogenes protects against heterologous lethal challenge, this early protection is nonspecific. |
| Databáze: | OpenAIRE |
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