Reduction of renal function during mechanical ventilation of healthy lungs in an animal biomodel
| Autor: | Lumir Sasek, J Kobr, K Pizingerova, J Koppl, P Jehlicka, Hes O, J Fremuth, Racek J, R Hrdlicka |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Economics and Econometrics Fractional excretion of sodium Swine medicine.medical_treatment Positive pressure Renal function Hemodynamics Kidney Kidney Function Tests Positive-Pressure Respiration Random Allocation Reference Values Materials Chemistry Media Technology Tidal Volume Medicine Animals Renal Insufficiency Tidal volume Mechanical ventilation business.industry Forestry Respiration Artificial Free water clearance Disease Models Animal Anesthesia Breathing business Biomarkers |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0006-9248 |
| Popis: | Objectives: To identify factors involved in reno-pulmonary interactions during mechanical ventilation. Materials and methods: The study included a total of 25 domestic piglets. The animals were divided into three groups based on different strategies of ventilation. Group A; spontaneously breathing piglets; group B animals ventilated with tidal volume of 6 ml.kg-1 and group C with animals ventilated with tidal volume 10 ml.kg-1. Clini- cal monitoring and laboratory tests were performed for all groups at baseline and then at 1 hour and 12 hours for groups B and C. Ventilation indices, hemodynamics, urine output, creatinine clearance, glomerular fi ltration index, fractional excretion of sodium, free water clearance and tissue samples were recorded. The data ob- tained were statistically analysed. Results: Lower creatinine clearance and renal indices were seen in group B (p < 0.05) and in group C (p < 0.001) at 1 hour, and a difference in urine output for group C (p < 0.01) compared to group A was observed. At 12 hours, there was a further reduction in creatinine clearance and renal indices for group B (p < 0.05) and group C (p < 0.01). The lung mechanics and hemodynamics were not signifi cantly infl uenced. Conclusions: The study showed a causal relationship between renal dysfunction and positive pressure mechani- cal ventilation with respect to tidal volume and time (Tab. 4, Fig. 2, Ref. 17). Text in PDF www.elis.sk. |
| Databáze: | OpenAIRE |
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