Gallstone disease in severely obese children participating in a lifestyle intervention program

Autor: Heida, A., Koot, B. G. P., van der Baan-Slootweg, O. H., Rijcken, T. H. Pels, Seidell, J. C., Makkes, S., Jansen, P. L. M., Benninga, M. A., Heida, Anke
Přispěvatelé: Epidemiology and Data Science, EMGO - Lifestyle, overweight and diabetes, Health Sciences, Health Economics and Health Technology Assessment, Atoms, Molecules, Lasers, EMGO+, Amsterdam Gastroenterology Endocrinology Metabolism, Paediatric Gastroenterology, Gastroenterology and Hepatology
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Pediatrics
Pediatric Obesity
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Body Mass Index
Cohort Studies
Cholelithiasis
Weight loss
Behavior Therapy
Risk Factors
ADOLESCENTS
Prevalence
Medicine
Prospective Studies
Morbid
Prospective cohort study
Child
Non-U.S. Gov't
INDEX
Netherlands
Nutrition and Dietetics
Research Support
Non-U.S. Gov't
Incidence
Gallstones
Obesity
Morbid
PREVALENCE
Weight Reduction Programs
Cohort
Female
medicine.symptom
Cohort study
medicine.medical_specialty
Adolescent
WEIGHT-LOSS
Research Support
SDG 3 - Good Health and Well-being
Weight Loss
Journal Article
Humans
Cholecystectomy
Obesity
Risk factor
business.industry
lifestyle intervention
medicine.disease
Surgery
pediatric
gallstone disease
weight loss
business
Weight gain
Body mass index
Risk Reduction Behavior
cholelithiasis
Zdroj: International Journal of Obesity, 38(7), 950-953. Nature Publishing Group
International journal of obesity (2005), 38(7), 950-953. Nature Publishing Group
Heida, A, Koot, B G P, van der Baan-Slootweg, O H, Rijcken, T H P, Seidell, J C, Makkes, S, Jansen, P L M & Benninga, M A 2014, ' Gallstone disease in severely obese children participating in a lifestyle intervention program: incidence and risk factors. ', International Journal of Obesity, vol. 38, no. 7, pp. 950-953 . https://doi.org/10.1038/ijo.2014.12
Heida, A, Koot, B G P, vd Baan-Slootweg, O H, Pels Rijcken, T H, Seidell, J C, Makkes, S, Jansen, P L M & Benninga, M A 2014, ' Gallstone disease in severely obese children participating in a lifestyle intervention program : incidence and risk factors ', International Journal of Obesity, vol. 38, no. 7, pp. 950-953 . https://doi.org/10.1038/ijo.2014.12
ISSN: 1476-5497
0307-0565
Popis: INTRODUCTION: Cholelithiasis is increasingly encountered in childhood and adolescence due to the rise in obesity. As in adults, weight loss is presumed to be an important risk factor for cholelithiasis in children, but this has not been studied.METHODS: In a prospective observational cohort study we evaluated the presence of gallstones in 288 severely obese children and adolescents (mean age 14.1 +/- 2.4 years, body mass index (BMI) z-score 3.39 +/- 0.37) before and after participating in a 6-month lifestyle intervention program.RESULTS: During the lifestyle intervention, 17/288 children (5.9%) developed gallstones. Gallstones were only observed in those losing >10% of initial body weight and the prevalence was highest in those losing >25% of weight. In multivariate analysis change in BMI z-score (odds ratio (OR) 3.26 (per 0.5 s.d. decrease); 95% CI: 1.60-6.65) and baseline BMI z-score (OR 2.32 (per 0.5 s.d.); 95% CI: 1.16-4.70) were independently correlated with the development of gallstones. Sex, family history, OAC use, puberty and biochemistry were not predictive in this cohort. During post-treatment follow-up (range 0.4-7.8 years) cholecystectomy was performed in 22% of those with cholelithiasis. No serious complications due to gallstones occurred.CONCLUSION: The risk of developing gallstones in obese children and adolescents during a lifestyle intervention is limited and mainly related to the degree of weight loss and initial body weight.
Databáze: OpenAIRE
Externí odkaz: