Gallstone disease in severely obese children participating in a lifestyle intervention program
Autor: | Heida, A., Koot, B. G. P., van der Baan-Slootweg, O. H., Rijcken, T. H. Pels, Seidell, J. C., Makkes, S., Jansen, P. L. M., Benninga, M. A., Heida, Anke |
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Přispěvatelé: | Epidemiology and Data Science, EMGO - Lifestyle, overweight and diabetes, Health Sciences, Health Economics and Health Technology Assessment, Atoms, Molecules, Lasers, EMGO+, Amsterdam Gastroenterology Endocrinology Metabolism, Paediatric Gastroenterology, Gastroenterology and Hepatology |
Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
Male
Pediatrics Pediatric Obesity Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Body Mass Index Cohort Studies Cholelithiasis Weight loss Behavior Therapy Risk Factors ADOLESCENTS Prevalence Medicine Prospective Studies Morbid Prospective cohort study Child Non-U.S. Gov't INDEX Netherlands Nutrition and Dietetics Research Support Non-U.S. Gov't Incidence Gallstones Obesity Morbid PREVALENCE Weight Reduction Programs Cohort Female medicine.symptom Cohort study medicine.medical_specialty Adolescent WEIGHT-LOSS Research Support SDG 3 - Good Health and Well-being Weight Loss Journal Article Humans Cholecystectomy Obesity Risk factor business.industry lifestyle intervention medicine.disease Surgery pediatric gallstone disease weight loss business Weight gain Body mass index Risk Reduction Behavior cholelithiasis |
Zdroj: | International Journal of Obesity, 38(7), 950-953. Nature Publishing Group International journal of obesity (2005), 38(7), 950-953. Nature Publishing Group Heida, A, Koot, B G P, van der Baan-Slootweg, O H, Rijcken, T H P, Seidell, J C, Makkes, S, Jansen, P L M & Benninga, M A 2014, ' Gallstone disease in severely obese children participating in a lifestyle intervention program: incidence and risk factors. ', International Journal of Obesity, vol. 38, no. 7, pp. 950-953 . https://doi.org/10.1038/ijo.2014.12 Heida, A, Koot, B G P, vd Baan-Slootweg, O H, Pels Rijcken, T H, Seidell, J C, Makkes, S, Jansen, P L M & Benninga, M A 2014, ' Gallstone disease in severely obese children participating in a lifestyle intervention program : incidence and risk factors ', International Journal of Obesity, vol. 38, no. 7, pp. 950-953 . https://doi.org/10.1038/ijo.2014.12 |
ISSN: | 1476-5497 0307-0565 |
Popis: | INTRODUCTION: Cholelithiasis is increasingly encountered in childhood and adolescence due to the rise in obesity. As in adults, weight loss is presumed to be an important risk factor for cholelithiasis in children, but this has not been studied.METHODS: In a prospective observational cohort study we evaluated the presence of gallstones in 288 severely obese children and adolescents (mean age 14.1 +/- 2.4 years, body mass index (BMI) z-score 3.39 +/- 0.37) before and after participating in a 6-month lifestyle intervention program.RESULTS: During the lifestyle intervention, 17/288 children (5.9%) developed gallstones. Gallstones were only observed in those losing >10% of initial body weight and the prevalence was highest in those losing >25% of weight. In multivariate analysis change in BMI z-score (odds ratio (OR) 3.26 (per 0.5 s.d. decrease); 95% CI: 1.60-6.65) and baseline BMI z-score (OR 2.32 (per 0.5 s.d.); 95% CI: 1.16-4.70) were independently correlated with the development of gallstones. Sex, family history, OAC use, puberty and biochemistry were not predictive in this cohort. During post-treatment follow-up (range 0.4-7.8 years) cholecystectomy was performed in 22% of those with cholelithiasis. No serious complications due to gallstones occurred.CONCLUSION: The risk of developing gallstones in obese children and adolescents during a lifestyle intervention is limited and mainly related to the degree of weight loss and initial body weight. |
Databáze: | OpenAIRE |
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