Antimicrobial Coatings from Hybrid Nanoparticles of Biocompatible and Antimicrobial Polymers
| Autor: | Beatriz Ideriha Mathiazzi, Carolina Nascimento Galvão, Ana Maria Carmona-Ribeiro, Rodrigo Tadeu Ribeiro, Denise Freitas Siqueira Petri, Luccas Missfeldt Sanches |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Polymers
Nanoparticle Staphylococcus aureus 02 engineering and technology coatings wettability 01 natural sciences lcsh:Chemistry chemistry.chemical_compound Coated Materials Biocompatible bacteria viability lcsh:QH301-705.5 bactericidal coatings Spectroscopy chemistry.chemical_classification coatings from nanoparticles dynamic light scattering General Medicine Polymer 021001 nanoscience & nanotechnology Anti-Bacterial Agents Computer Science Applications microbicidal coatings 0210 nano-technology biocompatible polymer Ammonium bromide Materials science Emulsion polymerization Microbial Sensitivity Tests 010402 general chemistry Article Catalysis Inorganic Chemistry Surface-Active Agents Antimicrobial polymer Escherichia coli Polymethyl Methacrylate Colloids Physical and Theoretical Chemistry Molecular Biology antimicrobial polymer Organic Chemistry Cationic polymerization 0104 chemical sciences Quaternary Ammonium Compounds lcsh:Biology (General) lcsh:QD1-999 chemistry Polymerization Chemical engineering Solvents Nanoparticles ESCHERICHIA COLI Polystyrene Polyethylenes |
| Zdroj: | International Journal of Molecular Sciences Volume 19 Issue 10 International Journal of Molecular Sciences, Vol 19, Iss 10, p 2965 (2018) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms19102965 |
| Popis: | Hybrid nanoparticles of poly(methylmethacrylate) synthesized in the presence of poly (diallyldimethyl ammonium) chloride by emulsion polymerization exhibited good colloidal stability, physical properties, and antimicrobial activity but their synthesis yielded poor conversion. Here we create antimicrobial coatings from casting and drying of the nanoparticles dispersions onto model surfaces such as those of silicon wafers, glass coverslips, or polystyrene sheets and optimize conversion using additional stabilizers such as cetyltrimethyl ammonium bromide, dioctadecyldimethyl ammonium bromide, or soybean lecithin during nanoparticles synthesis. Methodology included dynamic light scattering, determination of wettability, ellipsometry of spin-coated films, scanning electron microscopy, and determination of colony forming unities (log CFU/mL) of bacteria after 1 h interaction with the coatings. The additional lipids and surfactants indeed improved nanoparticle synthesis, substantially increasing the conversion rates by stabilizing the monomer droplets in dispersion during the polymerization. The coatings obtained by spin-coating or casting of the nanoparticles dispersions onto silicon wafers were hydrophilic with contact angles increasing with the amount of the cationic polymer in the nanoparticles. Against Escherichia coli and Staphylococcus aureus, bacteria cell counts were reduced by approximately 7 logs upon interaction with the coatings, revealing their potential for several biotechnological and biomedical applications. |
| Databáze: | OpenAIRE |
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