Immunomodulating activity of DW-116, a new quinolone antibiotic
| Autor: | Eun-Yi Moon, Suhkneung Pyo, Yong Ho Chung, Chung Ha Choi, Dug Keun Lee, Sung June Yoon |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Hydrochloride Hemolytic Plaque Technique Microbial Sensitivity Tests Quinolones Lymphocyte Activation Piperazines Microbiology Mice chemistry.chemical_compound Adjuvants Immunologic Anti-Infective Agents Quinolone antibiotic Drug Discovery medicine Animals Hypersensitivity Delayed Lymphocytes Mice Inbred BALB C T-lymphocyte proliferation Bacteria biology Organic Chemistry biology.organism_classification In vitro Immunoglobulin M Mechanism of action chemistry Polyclonal antibodies biology.protein Molecular Medicine medicine.symptom Antibody Cell Division Spleen Fluoroquinolones |
| Zdroj: | Archives of Pharmacal Research. 21:610-614 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/bf02975383 |
| Popis: | DW-116, (1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1-piperazinyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride), is a new quinolone antibiotic with a broad antibacterial spectrum against G(+) and G(-) bacteria. DW-116 was evaluated for the immunomodulating activities, which is one of the efforts to investigate the mechanism of action related to the good in vivo antibacterial efficacy. The results of in vitro studies revealed there was no statistically significant increase in B and T lymphocyte proliferation. But the results of in vivo studies showed that the number of plaque forming cells (PFC), the amount of polyclonal antibodies and delayed-type hypersensitivity (DTH) were significantly increased after the repeat administration with 12 and 60 mg/kg of DW-116. Taken together, these results proposed that immunostimulating effect of DW-116 could be one of the action mechanisms for demonstrating in vivo antibacterial activities under these experimental conditions. |
| Databáze: | OpenAIRE |
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