Combined use of D-dimer and P-selectin for the diagnosis of splenic or portal vein thrombosis following splenectomy
| Autor: | Huai-Ping Dong, Yan-Xin Chen, Li Wang, Lexin Wang, Gui-Jie Liu, Yan-Qiang Zhang |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Cirrhosis P-selectin medicine.medical_treatment Splenectomy Sensitivity and Specificity Gastroenterology Fibrin Fibrinogen Degradation Products Internal medicine D-dimer medicine Humans Prospective cohort study Aged Venous Thrombosis Portal Vein business.industry Reproducibility of Results Hematology Middle Aged medicine.disease Portal vein thrombosis Surgery P-Selectin Splenic Vein Splenic vein Portal hypertension Female business |
| Zdroj: | Thrombosis Research. 125:e206-e209 |
| ISSN: | 0049-3848 |
| Popis: | To investigate the predictive value of combined use of D-dimer and P-selectin for splenic or portal vein thrombosis (SPVT) after splenectomy. A prospective study was carried out in 82 patients who had undergone splenectomy for portal hypertension secondary to hepatic cirrhosis. Plasma levels D-dimer and P-selectin were measured before and after the surgery.27 (30.1%) patients developed SPVT following the portal hypertension surgery. The post-operative D-dimer and P-selectin levels in patients with SPVT were significantly higher than in those without PVT (n=55, P0.01). The receiver-operated characteristics curves (ROC) of D-dimer and P-selectin showed a significant predictive value in SPVT (D-dimer, Az=0.880, P0.01; P-slectin, Az=0.933, P0.01). The sensitivity and specificity of D-dimer (500 microg/mL) in diagnosing SPVT were 88.9% and 78.2% respectively. P-selectin90ng/mL had an 85.2% sensitivity and 85.5% specificity for SPVT. The combination of the D-dimer and P-selectin criteria yielded an 82.0% sensitivity and 97.6% specificity for SPVT. In Conclusion, there was a significant elevation in plasma D-dimer and P-selectin in patients with post-operative SPVT. A combination of plasma D-dimer and P-selectin may be used as biomarkers to screen or diagnose SPVT following splenectomy. |
| Databáze: | OpenAIRE |
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