Anti-ST2 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected mice
| Autor: | Yu-Tzu Huang, Wen-Yuan Du, Chih-Cheng Chuang, Chi-Wu Chen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) medicine.drug_class medicine.medical_treatment Intraperitoneal injection Booster dose Biology Monoclonal antibody Pathogenesis 03 medical and health sciences Meninges 0302 clinical medicine Immunology and Microbiology(all) medicine Animals Immunology and Allergy Strongylida Infections General Immunology and Microbiology Angiostrongylus cantonensis Antibodies Monoclonal Receptors Interleukin General Medicine Eosinophil Interleukin-33 ST2 medicine.disease biology.organism_classification Interleukin-1 Receptor-Like 1 Protein Eosinophils Mice Inbred C57BL Interleukin 33 Treatment Outcome 030104 developmental biology Infectious Diseases medicine.anatomical_structure Immunology Infiltration (medical) 030215 immunology |
| Zdroj: | Journal of Microbiology, Immunology and Infection. 49:91-96 |
| ISSN: | 1684-1182 |
| DOI: | 10.1016/j.jmii.2014.01.009 |
| Popis: | Background/Purpose Interleukin-33 (IL-33) could play an important role in the pathogenesis of angiostrongylosis. However, the role of IL-33/ST2 pathway in this parasitic infection is uncertain. Methods C57BL/six mice were each infected with 35 Angiostrongylus cantonensis larvae. One group of mice received an intraperitoneal injection of anti-ST2 monoclonal antibody (mAb; 50 μg) 3 days postinfection and subsequent booster shots of the same dose at 5-day intervals. Blood samples from each group were collected every week for assays. Results The level of IL-5 significantly decreased in the mAb-treated group, and the infiltration of eosinophils in the meninges was also significantly reduced. Conclusion The IL-33/ST2 axis may play a crucial role in the pathogenesis of angiostrongylosis and the results of this study could be useful for the development of strategies to reduce the neurological damage caused by this parasitic infection. |
| Databáze: | OpenAIRE |
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