Chitosan: potential use as a bioactive coating for orthopaedic and craniofacial/dental implants
| Autor: | Patrick D. Gerard, Victoria Ramsey, Robin Wiser, Joel D. Bumgardner, Patrick F. Bergin, Steve H. Elder, Jerome A. Gilbert, Betsy Chestnutt, Mark Marini |
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| Rok vydání: | 2003 |
| Předmět: |
Materials science
Surface Properties Cell Culture Techniques Biomedical Engineering Biophysics chemistry.chemical_element Chitin Bioengineering engineering.material Bone and Bones Osseointegration Biomaterials Chitosan chemistry.chemical_compound Coated Materials Biocompatible Tensile Strength Ultimate tensile strength Cell Adhesion Humans Composite material Dissolution Dental Implants Titanium Orthopedic Equipment Bond strength Prostheses and Implants Silanes Orthopedics Solubility chemistry engineering Biopolymer Implant |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 14:423-438 |
| ISSN: | 1568-5624 0920-5063 |
| Popis: | Chitosan is a biopolymer that exhibits osteoconductive, enhanced wound healing and antimicrobial properties which make it attractive for use as a bioactive coating to improve osseointegration of orthopaedic and craniofacial implant devices. Coatings made from 91.2% de-acetylated chitosan were chemically bonded to titanium coupons via silane-glutaraldehyde molecules. The bond strength of the coatings was evaluated in mechanical tensile tests, and their dissolution and cytocompatibility were evaluated in vitro using cell-culture medium and UMR 106 osteoblastic cells, respectively. The results showed that the chitosan coatings were chemically bonded to the titanium substrate and that the bond strengths (1.5-1.8 MPa) were not affected by gas sterilization. However, the chitosan bond strengths were less than those reported for calcium-phosphate coatings. The gas-sterilized coatings exhibited little dissolution over 8 weeks in cell-culture solution, and the attachment and growth of the UMR 106 osteoblast cells was greater on the chitosan-coated samples than on the uncoated titanium. These results indicated that chitosan has the potential to be used as a biocompatible, bioactive coating for orthopaedic and craniofacial implant devices. |
| Databáze: | OpenAIRE |
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