Persistent diarrhoea in Zairian AIDS patients: an endoscopic and histological study
| Autor: | I. Lebughe, R Colebunders, Henry Francis, E van Marck, K Lusakumuni, Thomas C. Quinn, Gigase Pl, Ann M. Nelson, Bila Kapita, J J Salaun |
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| Rok vydání: | 1988 |
| Předmět: |
Diarrhea
Male medicine.medical_specialty Pathology Intestinal parasite medicine.disease_cause Gastroenterology Strongyloides stercoralis Feces Intestinal mucosa Internal medicine HIV Seropositivity parasitic diseases Humans Medicine Intestinal Mucosa biology business.industry Endoscopy biology.organism_classification Isospora medicine.anatomical_structure Democratic Republic of the Congo Etiology Duodenum Female Viral disease medicine.symptom business Research Article |
| Zdroj: | Gut. 29:1687-1691 |
| ISSN: | 0017-5749 |
| Popis: | To determine the aetiology of persistent diarrhoea in African patients with acquired immunodeficiency syndrome (AIDS), 42 patients with human immunodeficiency virus (HIV) and persistent diarrhoea were enrolled in a microbiological, endoscopic, and histological study. Cryptosporidium was the intestinal parasite most often identified (30%); Isospora belli was found in 12% of the patients. Histological examination of the duodenal mucosa showed a non-specific inflammatory reaction in a significantly higher number of HIV-seropositive patients (82%) than HIV-seronegative controls without diarrhoea (52%) (p = 0.02). Lymphocytes were more likely to be found in inflammatory reactions in HIV-seropositive patients than in controls (p less than 0.0001). Pathogens were observed in histological sections of the duodenum of HIV-seropositive patients only (p = 0.002) and included cryptosporidia (four patients) Isospora belli (one), Strongyloides stercoralis (one), and Cryptococcus neoformans (one). On histological examination the rectal mucosa of HIV-seropositive patients and controls was similar, except eosinophils were more likely to be present in inflammatory reaction in HIV-seropositive patients (p = 0.05) and enteric pathogens were observed only in HIV-seropositive patients (cytomegalovirus inclusion bodies (one) and Schistosoma mansoni (two). The aetiology of persistent diarrhoea in most African AIDS patients remains unclear. |
| Databáze: | OpenAIRE |
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