Lupus anticoagulant in the elderly may be associated with both quinine and quinidine usage
| Autor: | Margaret R. Bird, Kamal Ibrahim, J. Des Parkin, Russell R C Buchanan, Anthony I. O’Neill |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Drug Quinidine medicine.medical_specialty medicine.drug_class media_common.quotation_subject Pharmacology Pathology and Forensic Medicine Antiphospholipid syndrome Internal medicine medicine Coagulopathy Humans Aged Retrospective Studies media_common Aged 80 and over Lupus anticoagulant Quinine Systemic lupus erythematosus business.industry Anticoagulant Antiphospholipid Syndrome medicine.disease Lupus Coagulation Inhibitor Female business medicine.drug |
| Zdroj: | Pathology. 27:136-139 |
| ISSN: | 0031-3025 |
| DOI: | 10.1080/00313029500169742 |
| Popis: | Thirty-one patients aged over 60 yrs and with lupus anticoagulant (LA) were reviewed for their drug intake. Twenty-three (73%) were taking cinchona alkaloids, 10 (32%) quinine for night cramps, 11 (35%) quinidine for cardiac arrhythmia and 2 (6%) were taking both. These frequencies of drugs usage differed significantly from age and sex matched controls (p < 0.001). Five patients had features suggestive of the antiphospholipid syndrome. Repeat testing showed persistent LA activity in all but 2 of 5 patients in whom the relevant drug had been ceased. This is the first description of a possible causal association between LA and quinine therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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