Aplastic Anemia during Growth Hormone (GH) Treatment in a Girl with Idiopathic GH-Deficiency
| Autor: | Keiichi Hanaki, Atsushi Hayashi, Shuji Sugimoto, Susumu Kanzaki, Tomoe Kinoshita, Jun-ichi Nagaishi, Yuki Kawashima |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Trisomy Trisomy 8 Methylprednisolone Endocrinology Megakaryocyte White blood cell Internal medicine medicine Humans Aplastic anemia Child Glucocorticoids Antilymphocyte Serum medicine.diagnostic_test Human Growth Hormone business.industry Anemia Aplastic medicine.disease Recombinant Proteins Bone marrow examination Leukemia medicine.anatomical_structure Female Bone marrow business Immunosuppressive Agents Chromosomes Human Pair 8 |
| Zdroj: | Endocrine Journal. 50:469-471 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.50.469 |
| Popis: | We report a 12-year-old girl with aplastic anemia accompanied by chromosome 8 trisomy during growth hormone (GH) therapy. When she was six years old she was diagnosed as idiopathic isolated GH deficiency, and GH therapy (0.175 mg/kg/week) was initiated. At the age 12, she began to exhibit petechiae in both lower limbs. Platelet count was 11,000/microL; serum hemoglobin level 11.8 gr/mL; white blood cell count 3,400/microL, with 37% neutrophils, 58% lymphocytes, 4% monocytes and 1% basophils. Bone marrow examination showed that total nucleated cell count and megakaryocyte were 17,000/microL and 0/microL, respectively, suggesting low formation. In addition, 13% of bone marrow cells contained the 3 signals of chromosome 8 marker (trisomy 8). She was diagnosed as aplastic anemia accompanied with chromosome 8 trisomy. GH therapy was stopped immediately, and simultaneous administration of methylprednisolone and anti-thymocyte globulin was initiated. Platelet count improved with treatment, and the 3-signal chromosome 8 abnormality disappeared from the bone marrow cells. The fact that a hematological adverse effect other than leukemia exists in conjunction with GH therapy warrants further investigation into possible hematological changes occurring during or after GH therapy. |
| Databáze: | OpenAIRE |
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