Axially Ligated Mesohemins as Bio-Mimicking Catalysts for Atom Transfer Radical Polymerization
| Autor: | Yi Wang, Antonina Simakova, Marco Fantin, Sangwoo Park, Liye Fu, Krzysztof Matyjaszewski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Porphyrins
Polymers Iron Dispersity Pharmaceutical Science Sulfides 010402 general chemistry 01 natural sciences Article Catalysis Analytical Chemistry Polymerization lcsh:QD241-441 chemistry.chemical_compound Hemoglobins lcsh:Organic chemistry ATRPase Bio-mimicking catalyst Heme Iron porphyrin Iron-mediated ATRP Copper Cytochrome P-450 Enzyme System Horseradish Peroxidase Imidazoles Molecular Structure Oxidation-Reduction Biomimetics Thioether Drug Discovery Polymer chemistry Imidazole heterocyclic compounds Physical and Theoretical Chemistry heme bio-mimicking catalyst chemistry.chemical_classification 010405 organic chemistry Atom-transfer radical-polymerization Organic Chemistry iron-mediated ATRP Polymer Porphyrin 0104 chemical sciences chemistry Chemistry (miscellaneous) Molecular Medicine iron porphyrin |
| Zdroj: | Molecules Volume 24 Issue 21 Molecules, Vol 24, Iss 21, p 3969 (2019) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules24213969 |
| Popis: | Copper is the most common metal catalyst used in atom transfer radical polymerization (ATRP), but iron is an excellent alternative due to its natural abundance and low toxicity compared to copper. In this work, two new iron-porphyrin-based catalysts inspired by naturally occurring proteins, such as horseradish peroxidase, hemoglobin, and cytochrome P450, were synthesized and tested for ATRP. Natural protein structures were mimicked by attaching imidazole or thioether groups to the porphyrin, leading to increased rates of polymerization, as well as providing polymers with low dispersity, even in the presence of ppm amounts of catalysts. |
| Databáze: | OpenAIRE |
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