Chronic methylphenidate regulates genes and proteins mediating neuroplasticity in the juvenile brain
| Autor: | Estabraq Jaddoa, Tiziana Sgamma, Tyra S.C. Zetterström, Emmanuel Quansah |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Cerebellum Dendritic spine methylphenidate Striatum Nucleus accumbens Dendritic spines Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Internal medicine Neuroplasticity mental disorders medicine Animals ADHD IRSp53 Neuronal Plasticity Arc (protein) Cerebrum Methylphenidate General Neuroscience Brain Arc Rats 030104 developmental biology medicine.anatomical_structure Endocrinology Gene Expression Regulation nervous system Central Nervous System Stimulants Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Popis: | The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link Methylphenidate (MPH) is the front-line psychostimulant medication prescribed for alleviating the symptoms associated with attention deficit hyperactivity disorder (ADHD) in children. Here, we investigated the effects of chronic MPH (2.0 mg/kg, twice daily for 15 days) exposure to young rats (20-25 days old at start of treatment) on the expression of genes and proteins associated with neuroplasticity, such as activity regulated cytoskeleton-associated protein (Arc), insulin receptor substrate protein 53 (IRSp53), cell division control protein 42 (Cdc42), and actin-related protein 2 (Arp2). Chronic MPH increased Arc expression in areas of the cerebrum including, the striatum, nucleus accumbens and hippocampus. In addition, chronic MPH also increased the expression of IRSp53 in the striatum, while Cdc42 and Arp2 were specifically increased in the nucleus accumbens. Conversely, chronic MPH decreased Arc and IRSp53 protein expression in the cerebellum, indicating differential effects of the drug in cerebral areas relative to the cerebellum. Overall, our results indicate that chronic MPH treatment increases expression of genes and proteins associated with dendritic spine formation and neuronal plasticity in target areas of the cerebrum while it decreases the expression in the cerebellum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|