An Expedient Route to 9-arylmethylanthracene Derivatives via Tandem Ni-catalyzed Alkene Dicarbofunctionalization and Acid-promoted Cyclization-aromatization
| Autor: | Ramesh Giri, Bijay Shrestha, Roshan K. Dhungana, Doleshwar Niroula, Rishi R. Sapkota |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Tandem 010405 organic chemistry Chemistry Alkene Aryl One-pot synthesis Aromatization Regioselectivity General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Article 0104 chemical sciences Catalysis chemistry.chemical_compound Reagent |
| Zdroj: | Isr J Chem |
| ISSN: | 0021-2148 |
| Popis: | We report a nickel-catalyzed one pot synthesis of 9-arylmethylanthracene motifs, which find applications in medicinal and material chemistry. In this synthesis, we apply three component alkene dicarbofunctionalization of 2-vinylaldimines with aryl iodides and arylzinc reagent to generate a 1,1,2-diarylethyl scaffold, which then undergoes an acidpromoted cyclization followed by aromatization to furnish 9-arylmethylanthracene cores. With the new method, a number of differently-substituted 9-arylmethylanthracene derivatives can be synthesized in good yields. |
| Databáze: | OpenAIRE |
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