The mineralization of hair follicle tissue. II. An in vitro study
| Autor: | E. I. F. Pearce, A. C. Smillie |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Calcium Phosphates
Male Endocrinology Diabetes and Metabolism Nucleation chemistry.chemical_element Calcium Mineralization (biology) chemistry.chemical_compound Follicle Endocrinology Calcification Physiologic X-Ray Diffraction Keratin medicine Animals Orthopedics and Sports Medicine Sulfhydryl Compounds Octacalcium phosphate Mercaptoethanol Skin chemistry.chemical_classification Supersaturation Proteins General Medicine Hair follicle Rats medicine.anatomical_structure Freeze Drying chemistry Biophysics Keratins Hydroxyapatites Crystallization Hair |
| Zdroj: | Calcified tissue research. 11(1) |
| ISSN: | 0008-0594 |
| Popis: | Hair follicle tissue from uninjured skin induced mineral formation in calcium phosphate solutions at a level of supersaturation equal to the lowest level resulting in the crystal growth and secondary nucleation of synthetic hydroxypatite. This indicates that follicle tissue contains an effective nucleator of calcium phosphate; a nucleator which could be responsible for the initial localization of mineral deposits to this tissue during skin calcificationin vivo. Hair clippings devoid of follicle tissue showed only a moderate nucleating ability. Follicle tissue which had been lyophilized and stored lost its nucleating ability, but the fact that the ability could be partly restored by treatment of the tissue with mercaptoethanol suggested that sulphydryl groups could be involved in the mechanism. The mineral precipitated from the barbitone-buffered calcifying solutions was nodular in appearance and showed the presence of octacalcium phosphate as well as hydroxyapative by X-ray diffraction. Inhibition of crystal growth and secondary nucleation by soluble follicle protein extracted into calcifying solutions was demonstrated and distinguished from the nucleation of solid mineral, phase by insoluble follicle proteins. |
| Databáze: | OpenAIRE |
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