Tracer kinetics and actions of oral and intraperitoneal 1,25-dihydroxyvitamin D3 administration in rats
| Autor: | Sang Whay Kooh, W. W. Tinmouth, J W Balfe, M. Rawlins, Reinhold Vieth |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Calcitriol medicine.medical_treatment Intraperitoneal injection chemistry.chemical_element Administration Oral Biological Availability Calcium Tritium Excretion Route of administration Pharmacokinetics Oral administration Internal medicine medicine Animals Rats Inbred Strains Bioavailability Rats Endocrinology chemistry Nephrology Injections Intraperitoneal medicine.drug |
| Zdroj: | Kidney International. 38(5):857-861 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.1990.282 |
| Popis: | Tracer kinetics and actions of oral and intraperitoneal 1,25-dihydroxy-vitamin D 3 administration in rats. Tracer kinetic parameters of [ 3 H]-1,25(OH) 2 D 3 were calculated from data obtained following its acute oral (p.o.) or intraperitoneal (i.p.) administration. In normal rats studied after the tracer had distributed into the body, the slope and intercept of the log-serum [ 3 H]-1,25(OH) 2 D 3 versus time relationship were not significantly influenced by the route of administration. Pretreatment with 1,25(OH) 2 D 3 (0.2 µg/100 g/day) by the same route as the tracer resulted in the following changes: in p.o. rats the serum [ 3 H]-1,25(OH) 2 D 3 intercept was much lower but the slope was not changed; in i.p. rats the intercept was not changed but the slope was increased. Both p.o. and i.p. treatment with 1,25(OH) 2 D 3 lowered the weight gain and diet consumption, and increased serum calcium, kidney tissue calcium and urinary excretion of orally administered 45 Ca. All the measures of bioactivity were greater in the i.p. dosed rats than in the p.o. dosed rats. We conclude that the p.o 1,25(OH) 2 D 3 was less potent because of diminished bioavailability due to self induction of its presystemic metabolism and inactivation. |
| Databáze: | OpenAIRE |
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