Effect of bioamines on the cellular differentiation of Hartmannella culbertsoni
| Autor: | Coimbatore R. Krishna Murti, Mohan K. Raizada, Anil Kumar Verma |
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| Rok vydání: | 1974 |
| Předmět: |
Biogenic Amines
Serotonin food.ingredient Epinephrine Dopamine Tyramine Cycloheximide Biochemistry Amoeba (genus) chemistry.chemical_compound Adenosine Triphosphate food parasitic diseases Cyclic AMP medicine Animals Carbon Radioisotopes Amoeba Axenic Protein kinase A Pharmacology Membranes biology Cell Differentiation biochemical phenomena metabolism and nutrition biology.organism_classification Stimulation Chemical Culture Media Cell biology chemistry Hartmannella Protein Biosynthesis Phosphorus Radioisotopes Protein Kinases Adenosine triphosphate medicine.drug |
| Zdroj: | Biochemical Pharmacology. 23:57-63 |
| ISSN: | 0006-2952 |
| Popis: | Epinephrine, 5-hydroxytryptamine, dopamine and tyramine induce axenic encystation of the free living amoeba Hartmannella culbertsoni . Cycloheximide inhibits encystation of amoeba mediated by the amines. The amines uniformly stimulate 3 to 4-fold the ability of the cells to synthesize cyclic 3′,5′-adenosine monophosphate from adenosine triphosphate formed in situ . Epinephrine[ 14 C] is bound to membranes of the amoeba ( K m of binding = 6.5 mM epinephrine). When amoebae are exposed to epinephrine, tyramine, dopamine or cAMP in a non-nutrient medium for 6 hr protein kinase activity is stimulated as evident from increased incorporation of 32 P into cellular proteins. |
| Databáze: | OpenAIRE |
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